Toshiya Kamiyama, Hideki Yokoo, Jun‐Ichi Furukawa, Masaki Kurogochi, Tomoaki Togashi, Nobuaki Miura, Kazuaki Nakanishi, Hirofumi Kamachi, Tatsuhiko Kakisaka, Yosuke Tsuruga, Masato Fujiyoshi, Akinobu Taketomi, Shin‐Ichiro Nishimura, Satoru Todo – 15 January 2013 – The altered N‐glycosylation of glycoproteins has been suggested to play an important role in the behavior of malignant cells. Using glycomics technology, we attempted to determine the specific and detailed N‐glycan profile for hepatocellular carcinoma (HCC) and investigate the prognostic capabilities.

Romain Desgrippes, Fabrice Lainé, Jeff Morcet, Michèle Perrin, Ghislain Manet, Caroline Jezequel, Edouard Bardou‐Jacquet, Martine Ropert, Yves Deugnier – 15 January 2013 – An excess of visceral adipose tissue could be involved as a modulator of the penetrance of HFE hemochromatosis since fat mass is associated with overexpression of hepcidin and low transferrin saturation was found to be associated with being overweight in women.

Petia Jeliazkova, Simone Jörs, Marcel Lee, Ursula Zimber‐Strobl, Jorge Ferrer, Roland M. Schmid, Jens T. Siveke, Fabian Geisler – 12 January 2013 – Notch signaling through the Notch2 receptor is essential for normal biliary tubulogenesis during liver development. However, the signaling events downstream of Notch2 critical for this process are less well defined. Furthermore, whether Notch signaling also underlies adult hepatic cell fate decisions is largely unknown.

Kerrilynn Carney, Sameer Dhalla, Ayse Aytaman, Craig T. Tenner, Fritz Francois – 12 January 2013 – Although injection drug use (IDU) and blood transfusions prior to 1992 are well‐accepted risk factors for hepatitis C virus (HCV) infection, many studies that evaluated tattooing as a risk factor for HCV infection did not control for a history of IDU or transfusion prior to 1992.

Xin‐Long Yan, Ya‐Li Jia, Lin Chen, Quan Zeng, Jun‐Nian Zhou, Chun‐Jiang Fu, Hai‐Xu Chen, Hong‐Feng Yuan, Zhi‐Wei Li, Lei Shi, Ying‐Chen Xu, Jing‐Xue Wang, Xiao‐Mei Zhang, Li‐Juan He, Chao Zhai, Wen Yue, Xue‐Tao Pei – 12 January 2013 – Cancer‐associated mesenchymal stem cells (MSCs) play a pivotal role in modulating tumor progression. However, the interactions between liver cancer‐associated MSCs (LC‐MSCs) and hepatocellular carcinoma (HCC) remain unreported. Here, we identified the presence of MSCs in HCC tissues.

Alina Pascale, Olivier Chazouillères, Lawrence Serfaty – 12 January 2013

Christopher E. McGowan, Ali Monis, Bruce R. Bacon, Josep Mallolas, Fernando L. Goncales, Ioannis Goulis, Fred Poordad, Nezam Afdhal, Stefan Zeuzem, Teerha Piratvisuth, Patrick Marcellin, Michael W. Fried – 12 January 2013 – Chronic infection with the hepatitis C virus (HCV) is a leading cause of global morbidity and mortality. Although recent advances in antiviral therapy have led to significant improvements in treatment response rates, only a minority of infected patients are treated. Multiple barriers may impede the delivery of HCV therapy.

Chad Walesky, Genea Edwards, Prachi Borude, Sumedha Gunewardena, Maura O'Neil, Byunggil Yoo, Udayan Apte – 12 January 2013 – Hepatocyte nuclear factor 4 alpha (HNF4α), the master regulator of hepatocyte differentiation, has been recently shown to inhibit hepatocyte proliferation by way of unknown mechanisms. We investigated the mechanisms of HNF4α‐induced inhibition of hepatocyte proliferation using a novel tamoxifen (TAM)‐inducible, hepatocyte‐specific HNF4α knockdown mouse model.

Angelina Mouralidarane, Junpei Soeda, Clara Visconti‐Pugmire, Anne‐Maj Samuelsson, Joaquim Pombo, Xanthi Maragkoudaki, Adil Butt, Ruma Saraswati, Marco Novelli, Guiseppe Fusai, Lucilla Poston, Paul D. Taylor, Jude A. Oben – 12 January 2013 – The global prevalence of obesity‐induced liver disease (nonalcoholic fatty liver disease; NAFLD) is rising. Suggested causes include a role for in utero influences of maternal obesity compounded by the availability of energy‐dense foods throughout postnatal life.

Wolfgang Sieghart, Florian Hucke, Matthias Pinter, Ivo Graziadei, Wolfgang Vogel, Christian Müller, Harald Heinzl, Michael Trauner, Markus Peck‐Radosavljevic – 12 January 2013 – We aimed to establish an objective point score to guide the decision for retreatment with transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC).