Hepatocyte caspase‐8 is an essential modulator of steatohepatitis in rodents

Maximilian Hatting, Gang Zhao, Fabienne Schumacher, Gernot Sellge, Malika Al Masaoudi, Nikolaus Gaβler, Mark Boekschoten, Michael Müller, Christian Liedtke, Francisco Javier Cubero, Christian Trautwein – 21 January 2013 – In human and murine models of nonalcoholic steatohepatitis (NASH), increased hepatocyte apoptosis is a critical mechanism contributing to inflammation and fibrogenesis. Caspase 8 (Casp8) is essential for death‐receptor‐mediated apoptosis activity and therefore its modulation might be critical for the pathogenesis of NASH.

Hepatic reticuloendothelial system cell iron deposition is associated with increased apoptosis in nonalcoholic fatty liver disease

Bryan D. Maliken, James E. Nelson, Heather M. Klintworth, Mary Beauchamp, Matthew M. Yeh, Kris V. Kowdley – 16 January 2013 – The aim of this study was to examine the relationship between the presence of hepatic iron deposition, apoptosis, histologic features, and serum markers of oxidative stress (OS) and cell death in nonalcoholic fatty liver disease (NAFLD). Clinical, biochemical, metabolic, and independent histopathologic assessment was conducted in 83 unselected patients with biopsy‐proven NAFLD from a single center.

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