Surgical assessment of significant steatosis in donor livers: The beginning of the end for frozen‐section analysis?
Elizabeth M. Brunt – 27 February 2013
Left hepatectomy versus right hepatectomy for living donor liver transplantation: Shifting the risk from the donor to the recipient
Garrett R. Roll, Justin R. Parekh, William F. Parker, Mark Siegler, Elizabeth A. Pomfret, Nancy L. Ascher, John Paul Roberts – 27 February 2013 – Living donor liver transplantation (LDLT), originally used in children with left lateral segment grafts, has been expanded to adults who require larger grafts to support liver function. Most adult LDLT procedures have been performed with right lobe grafts, and this means a significant risk of morbidity for the donors. To minimize the donor risk for adults, there is renewed interest in smaller left lobe grafts.
Down the liver sinusoidal endothelial cell (LSEC) hole. Is there a role for lipid rafts in LSEC fenestration?
Juan Rodriguez‐Vita, Manuel Morales‐Ruiz – 21 February 2013
Hepatitis C virus NS5B polymerase primes innate immune signaling
Gisa Gerold, Thomas Pietschmann – 21 February 2013
Sorafenib perpetuates cellular anticancer effector functions by modulating the crosstalk between macrophages and natural killer cells
Martin Franz Sprinzl, Florian Reisinger, Andreas Puschnik, Marc Ringelhan, Kerstin Ackermann, Daniel Hartmann, Matthias Schiemann, Arndt Weinmann, Peter Robert Galle, Marcus Schuchmann, Helmut Friess, Gerd Otto, Mathias Heikenwalder, Ulrike Protzer – 19 February 2013 – Alternatively polarized macrophages (Mϕ) shape the microenvironment of hepatocellular carcinoma (HCC) and temper anticancer immune responses. We investigated if sorafenib alters the HCC microenvironment by restoring classical macrophage polarization and triggering tumor‐directed natural killer (NK) cell responses.
Reply
Norah Terrault, Jennifer Dodge, Miriam Alter – 19 February 2013
Albumin: Pathophysiologic basis of its role in the treatment of cirrhosis and its complications
Rita Garcia‐Martinez, Paolo Caraceni, Mauro Bernardi, Pere Gines, Vicente Arroyo, Rajiv Jalan – 19 February 2013 – Since the introduction of human serum albumin as a plasma expander in the 1940s, considerable research has allowed a better understanding of its biochemical properties and potential clinical benefits. Albumin has a complex structure, which is responsible for a variety of biological functions. In disease, the albumin molecule is susceptible to modifications that may alter its biological activity.
Albumin: Pathophysiologic basis of its role in the treatment of cirrhosis and its complications
Rita Garcia‐Martinez, Paolo Caraceni, Mauro Bernardi, Pere Gines, Vicente Arroyo, Rajiv Jalan – 19 February 2013 – Since the introduction of human serum albumin as a plasma expander in the 1940s, considerable research has allowed a better understanding of its biochemical properties and potential clinical benefits. Albumin has a complex structure, which is responsible for a variety of biological functions. In disease, the albumin molecule is susceptible to modifications that may alter its biological activity.
Combination nucleos(t)ide analogue as initial treatment for chronic hepatitis B: Have we put this to rest?
Anna Suk‐Fong Lok – 19 February 2013
Alcohol dehydrogenase–specific T‐cell responses are associated with alcohol consumption in patients with alcohol‐related cirrhosis
Fang Lin, Nicholas J. Taylor, Haibin Su, Xiaohong Huang, Munther J. Hussain, Robin Daniel Abeles, Laura Blackmore, Yunyun Zhou, Mohammad Mashfick Ikbal, Nigel Heaton, Wayel Jassem, Debbie L. Shawcross, Diego Vergani, Yun Ma – 19 February 2013 – Patients with alcohol‐related liver disease (ALD) have antibodies directed to alcohol dehydrogenase (ADH), anti‐ADH titers being associated with disease severity and active alcohol consumption. ADH‐specific T‐cell responses have not been characterized.