Li Jiang, Anque Liao, Lunan Yan, Jiayin Yang – 15 November 2013

Yusuf Gunay, Necdet Guler, Murat Dayangac, Fatih Taskesen, Onur Yaprak, Ertan Emek, Murat Akyildiz, Gulum Altaca, Yildiray Yuzer, Yaman Tokat – 15 November 2013 – Living donor liver transplantation (LDLT) is an accepted option for end‐stage liver disease, particularly in countries in which there are organ shortages. However, little is known about LDLT for obese patients. We sought to determine the effects of obesity on pretransplant living donor selection for obese recipients and their outcomes.

Yunching Chen, Yuhui Huang, Thomas Reiberger, Annique M. Duyverman, Peigen Huang, Rekha Samuel, Lotte Hiddingh, Sylvie Roberge, Christina Koppel, Gregory Y. Lauwers, Andrew X. Zhu, Rakesh K. Jain, Dan G. Duda – 14 November 2013 – Sorafenib—a broad kinase inhibitor—is a standard therapy for advanced hepatocellular carcinoma (HCC) and has been shown to exert antifibrotic effects in liver cirrhosis, a precursor of HCC. However, the effects of sorafenib on tumor desmoplasia—and its consequences on treatment resistance—remain unknown.

Jian Sun, Qing Xie, Deming Tan, Qin Ning, Junqi Niu, Xuefan Bai, Rong Fan, Shijun Chen, Jun Cheng, Yanyan Yu, Hao Wang, Min Xu, Guangfeng Shi, Mobin Wan, Xinyue Chen, Hong Tang, Jifang Sheng, Xiaoguang Dou, Junping Shi, Hong Ren, Maorong Wang, Hongfei Zhang, Zhiliang Gao, Chengwei Chen, Hong Ma, Jidong Jia, Jinlin Hou – 14 November 2013 – An optimization strategy based on the Roadmap concept is supposed to improve the clinical outcomes of patients with suboptimal antiviral response. The aim of this study was to prove the concept with a multicenter, open‐label, randomized, controlled study.

Fateh Bazerbachi, Elizabeth Aby, John R. Lake – 10 November 2013

Yoo‐Mee Vanwijngaerden, Lies Langouche, Richard Brunner, Yves Debaveye, Marijke Gielen, Michael Casaer, Christopher Liddle, Sally Coulter, Pieter J. Wouters, Alexander Wilmer, Greet Berghe, Dieter Mesotten – 9 November 2013 – Cholestatic liver dysfunction (CLD) and biliary sludge often occur during critical illness and are allegedly aggravated by parenteral nutrition (PN). Delaying initiation of PN beyond day 7 in the intensive care unit (ICU) (late PN) accelerated recovery as compared with early initiation of PN (early PN).

Umut Safer, Vildan Binay Safer – 9 November 2013

Xiaodong Ge, Tung‐Ming Leung, Elena Arriazu, Yongke Lu, Raquel Urtasun, Brian Christensen, Maria Isabel Fiel, Satoshi Mochida, Esben S. Sørensen, Natalia Nieto – 9 November 2013 – Although osteopontin (OPN) is induced in alcoholic patients, its role in the pathophysiology of alcoholic liver disease (ALD) remains unclear. Increased translocation of lipopolysaccharide (LPS) from the gut is key for the onset of ALD because it promotes macrophage infiltration and activation, tumor necrosis factor‐α (TNFα) production, and liver injury.

Sam Lattimore, Will Irving, Sarah Collins, Celia Penman, Mary Ramsay, on Behalf of the Collaboration for the Sentinel Surveillance of Blood‐Borne Virus Testing – 9 November 2013 – The aim of this work was to develop and validate an algorithm to monitor rates of, and response to, treatment of patients infected with hepatitis C virus (HCV) across England using routine laboratory HCV RNA testing data. HCV testing activity between January 2002 and December 2011 was extracted from the local laboratory information systems of a sentinel network of 23 laboratories across England.

Takeshi Yamamura, Yuki Ohsaki, Michitaka Suzuki, Yuki Shinohara, Tsuyako Tatematsu, Jinglei Cheng, Masato Okada, Naoki Ohmiya, Yoshiki Hirooka, Hidemi Goto, Toyoshi Fujimoto – 9 November 2013 – Autophagy can degrade aggregate‐prone proteins, but excessive autophagy can have adverse effects. It would be beneficial if autophagy could be enhanced in a cell type‐specific manner, but this has been difficult because the basic mechanism of autophagy is common.