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Shalimar, Mohammed Faisal Sheikh, Rajeshwar P. Mookerjee, Banwari Agarwal, Subrat Kumar Acharya, Rajiv Jalan – 11 May 2019

CD8+ T Cells Promote Maturation of Liver‐Resident NK Cells Through the CD70‐CD27 axis

Lu Bai, Hui Peng, Xiaolei Hao, Ling Tang, Cheng Sun, Meijuan Zheng, Fubao Liu, Zhexiong Lian, Li Bai, Haiming Wei, Rui Sun, Zhigang Tian – 11 May 2019 – Liver‐resident natural killer (LrNK) cells are a unique subset of NK cells that are distinct from conventional NK cells. However, little is known about the mechanisms by which LrNK cells mature. In this study, we discovered that LrNK cells exhibit a relatively immature phenotype and impaired cytotoxic capacity in the absence of CD8+ T cells.

Integrated Omics Reveals Tollip as an Regulator and Therapeutic Target for Hepatic Ischemia‐Reperfusion Injury in Mice

Zhen‐Zhen Yan, Yong‐Ping Huang, Xin Wang, Hai‐Ping Wang, Fei Ren, Rui‐Feng Tian, Xu Cheng, Jie Cai, Yan Zhang, Xue‐Yong Zhu, Zhi‐Gang She, Xiao‐Jing Zhang, Zan Huang, Hongliang Li – 11 May 2019 – Hepatic ischemia‐reperfusion (IR) injury is the leading cause of liver dysfunction and failure after liver resection or transplantation and lacks effective therapeutic strategies. Here, we applied a systematic proteomic analysis to identify the prominent contributors to IR‐induced liver damage and promising therapeutic targets for this condition.

Deficient IL‐6/Stat3 Signaling, High TLR7, and Type I Interferons in Early Human Alcoholic Liver Disease: A Triad for Liver Damage and Fibrosis

Peter Stärkel, Bernd Schnabl, Sophie Leclercq, Mina Komuta, Ramon Bataller, Josepmaria Argemi, Elena Palma, Shilpa Chokshi, Claus Hellerbrand, Luca Maccioni, Nicolas Lanthier, Isabelle Leclercq – 10 May 2019 – Mechanisms underlying alcohol‐induced liver injury and its progression still remain incompletely understood. Animal models can only address some aspects of the pathophysiology that requires studies directly in humans, which are scarce.

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