A Prospective Study of the Prevalence of Parkinsonism in Patients With Liver Cirrhosis

Diana Apetauerova, Peter Hildebrand, Stephanie Scala, Janet W. Zani, LeeAnne Lipert, Erin Clark, Tanya Fennell, Fredric D. Gordon – 26 November 2020 – Acquired hepatocerebral degeneration refers to a neurological syndrome consisting of various movement disorders and cognitive impairment in advanced liver cirrhosis or portosystemic shunt. Neurological signs and symptoms may be attributed to the accumulation of toxic substances in the brain. The most common neurological presentation of this is parkinsonism.

Protein Phosphatase 1 Regulatory Subunit 3B Genotype at rs4240624 Has a Major Effect on Gallbladder Bile Composition

Ville Männistö, Dorota Kaminska, Pirjo Käkelä, Mikko Neuvonen, Mikko Niemi, Marcus Alvarez, Päivi Pajukanta, Stefano Romeo, Max Nieuwdorp, Albert.K. Groen, Jussi Pihlajamäki – 25 November 2020 – The protein phosphatase 1 regulatory subunit 3B (PPP1R3B) gene is a target of farnesoid X receptor (FXR), which is a major regulator of bile acid metabolism. Both PPP1R3B and FXR have been suggested to take part in glycogen metabolism, which may explain the association of PPP1R3B gene variants with altered hepatic computed tomography attenuation.

Hypothermic Oxygenated Perfusion Improves Extended Criteria Donor Liver Graft Function and Reduces Duration of Hospitalization Without Extra Cost: The PERPHO Study

Michel Rayar, Jean‐Marie Beaurepaire, Emma Bajeux, Stéphanie Hamonic, Thomas Renard, Clara Locher, Véronique Desfourneaux, Aude Merdrignac, Damien Bergeat, Mohamed Lakehal, Laurent Sulpice, Pauline Houssel‐Debry, Caroline Jezequel, Christophe Camus, Edouard Bardou‐Jacquet, Bernard Meunier – 25 November 2020 – Few studies have evaluated the efficacy or the cost of hypothermic oxygenated perfusion (HOPE) in the conservation of extended criteria donor (ECD) grafts from donation after brain death (DBD) donors during liver transplantation (LT).

Introducing EL‐FIT (Exercise and Liver FITness): A Smartphone App to Prehabilitate and Monitor Liver Transplant Candidates

Andrés Duarte‐Rojo, Pamela M. Bloomer, Renee J. Rogers, Mohamed A. Hassan, Michael A. Dunn, Amit D. Tevar, Samantha L. Vivis, Ramon Bataller, Christopher B. Hughes, Arny A. Ferrando, John M. Jakicic, W. Ray Kim – 24 November 2020 – Preserved physical function is key for successful liver transplantation (LT); however, prehabilitation strategies are underdeveloped. We created a smartphone application (app), EL‐FIT (Exercise and Liver FITness), to facilitate exercise training in end‐stage liver disease (ESLD).

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