Improvements of Fibrosis and Disease Activity Are Associated With Improvement of Patient‐Reported Outcomes in Patients With Advanced Fibrosis Due to Nonalcoholic Steatohepatitis

Zobair M. Younossi, Maria Stepanova, Mazen Noureddin, Kris V. Kowdley, Simone I. Strasser, Anita Kohli, Peter Ruane, Mitchell L. Shiffman, Aasim Sheikh, Nadege Gunn, Stephen H. Caldwell, Ryan S. Huss, Robert P. Myers, Vincent Wai‐Sun Wong, Naim Alkhouri, Zachary Goodman, Rohit Loomba – 11 May 2021 – Patient‐reported outcomes (PROs) are important endpoints for clinical trials. The impact of investigational drugs on PROs of patients with advanced nonalcoholic steatohepatitis (NASH) was investigated.

Doxycycline Significantly Enhances Induction of Induced Pluripotent Stem Cells to Endoderm by Enhancing Survival Through Protein Kinase B Phosphorylation

Caitlin Peaslee, Cristina Esteva‐Font, Tao Su, Antonio Munoz‐Howell, Caroline C. Duwaerts, Zhe Liu, Sneha Rao, Ke Liu, Marisa Medina, Julie B. Sneddon, Jacquelyn J. Maher, Aras N. Mattis – 11 May 2021

Management of Biliary Stricture in Pediatric Liver Transplantation Patients: Long‐Term Outcomes

Kimberly L. Yan, Antoinette S. Gomes, Phillip A. Monteleone, Robert S. Venick, Sue V. McDiarmid, Jorge H. Vargas, Douglas G. Farmer – 10 May 2021 – Postoperative biliary complications have been reported to occur in 10% to 33% of pediatric liver transplantation (LT) recipients. Percutaneous intervention has become the primary treatment method for these complications; however, the efficacy and outcomes of these patients have not been well studied.

A Systematic Review of Animal Models of NAFLD Finds High‐Fat, High‐Fructose Diets Most Closely Resemble Human NAFLD

Yu Ri Im, Harriet Hunter, Dana Gracia Hahn, Amedine Duret, Qinrong Cheah, Jiawen Dong, Madison Fairey, Clarissa Hjalmarsson, Alice Li, Hong Kai Lim, Lorcán McKeown, Claudia‐Gabriela Mitrofan, Raunak Rao, Mrudula Utukuri, Ian A. Rowe, Jake P. Mann – 10 May 2021

Human Leukocyte Antigen Profile Predicts Severity of Autoimmune Liver Disease in Children of European Ancestry

Yun Ma, Haibin Su, Muhammed Yuksel, Maria Serena Longhi, Mark J. McPhail, Pengyun Wang, Sanjay Bansal, Guan‐Wee Wong, Jonathon Graham, Li Yang, Richard Thompson, Derek G. Doherty, Nedim Hadzic, Yoh Zen, Alberto Quaglia, Michael A. Heneghan, Marianne Samyn, Diego Vergani, Giorgina Mieli‐Vergani – 9 May 2021

Impact of COVID‐19 in Liver Disease Progression

Miguel Angel Martinez, Sandra Franco – 8 May 2021 – Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) is a novel coronavirus that causes coronavirus disease 19 (COVID‐19), which has infected millions of people worldwide in only a few months. A minority, but significant number, of infected individuals require hospitalization and intensive care. From the start of this new virus pandemic, it was apparent that obese and/or diabetic individuals had a bad prognosis for COVID‐19 progression, strongly suggesting an association between liver disease and severe COVID‐19.

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