Ultrasensitive Assay for Hepatitis B Core‐Related Antigen Predicts Hepatocellular Carcinoma Incidences During Entecavir

Tetsuya Hosaka, Fumitaka Suzuki, Mariko Kobayashi, Shunichiro Fujiyama, Yusuke Kawamura, Hitomi Sezaki, Norio Akuta, Masahiro Kobayashi, Yoshiyuki Suzuki, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Hiromitsu Kumada – 15 September 2021 – Serum hepatitis B core‐related antigen (HBcrAg) and surface antigen (HBsAg) are surrogate markers of intrahepatic covalently closed circular DNA. The measurement range of the current HBcrAg assay is relatively narrow.

A Mesenchymal‐Epithelial Transition Factor‐Agonistic Antibody Accelerates Cirrhotic Liver Regeneration and Improves Mouse Survival Following Partial Hepatectomy

Kuai Ma, Weitao Que, Xin Hu, Wen‐Zhi Guo, Er‐li Gu, Liang Zhong, Virginia Morello, Manuela Cazzanti, Paolo Michieli, Terumi Takahara, Xiao‐Kang Li – 15 September 2021 – Small‐for‐size syndrome (SFSS) is a common complication following partial liver transplantation and extended hepatectomy. SFSS is characterized by postoperative liver dysfunction caused by insufficient regenerative capacity and portal hyperperfusion and is more frequent in patients with preexisting liver disease.

Early Everolimus‐Facilitated Reduced Tacrolimus in Liver Transplantation: Results From the Randomized HEPHAISTOS Trial

Björn Nashan, Peter Schemmer, Felix Braun, Hans J. Schlitt, Andreas Pascher, Christian G. Klein, Ulf P. Neumann, Irena Kroeger, Peter Wimmer, Hephaistos Study Group – 14 September 2021 – Everolimus‐facilitated reduced‐exposure tacrolimus (EVR + rTAC) at 30 days after liver transplantation (LT) has shown advantages in renal preservation. This study evaluated the effects of early initiation of EVR + rTAC in de novo LT recipients (LTRs).

Hepatology Highlights

Iman Waheed Khan, Muhammad Ashar Ali, Daryl T.Y. Lau, Thuy‐Van P. Hang, Preeti A. Reshamwala, Nidhi Jalan‐Sakrikar, Robert E. Schwartz, Shalil Khanal, Enis Kostallari, Anthony J. Choi, Robert S. Brown, Adebowale O. Bamidele, Davide Povero, Wei Zhang, Alyson Kaplan, Jeremy Louissaint, Nabeel Wahid, Jessica L. Maiers – 14 September 2021

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