Redefining Success After Liver Transplantation: From Mortality Toward Function and Fulfillment

Marina Serper, Sumeet Asrani, Lisa VanWagner, Peter P. Reese, Minjee Kim, Michael S. Wolf – 4 October 2021 – Liver transplantation (LT), the only cure for end‐stage liver disease, is a lifesaving, costly, and limited resource. LT recipients (LTRs) are aging with an increasing burden of medical comorbidities. Patient and graft survival rates exceed 70% at 5 years; however, patient‐centered health outcomes beyond survival have received relatively little attention.

Assessment of Deceased Brain Dead Donor Liver Grafts via Normothermic Machine Perfusion: Lactate Clearance Time Threshold Can Be Safely Extended to 6 Hours

Angus Hann, Hanns Lembach, Anisa Nutu, Hynek Mergental, John L. Isaac, John R. Isaac, Ye H. Oo, Matthew J. Armstrong, Neil Rajoriya, Simon Afford, David Bartlett, Darius F. Mirza, Hermien Hartog, M. Thamara P.R. Perera – 3 October 2021

Infusion of Allogeneic Mesenchymal Stromal Cells After Liver Transplantation: A 5‐Year Follow‐Up

Morgan Vandermeulen, Maleyko Mohamed‐Wais, Pauline Erpicum, Marie‐Hélène Delbouille, Chantal Lechanteur, Alexandra Briquet, Gianni Maggipinto, François Jouret, Yves Beguin, Olivier Detry – 2 October 2021 – Various properties of mesenchymal stromal cells (MSCs) might be particularly of interest after liver transplantation (LT). In this article, we report the long‐term results of a prospective, controlled, and first‐in‐human phase 1 study evaluating the safety of a single MSC infusion after LT.

Associations Between Alcohol Use and Liver‐Related Outcomes in a Large National Cohort of Patients With Cirrhosis

Meredith M. Pearson, Nicole J. Kim, Kristin Berry, Andrew M. Moon, Feng Su, Philip Vutien, Pamela K. Green, Emily C. Williams, George N. Ioannou – 2 October 2021 – Alcohol use can cause hepatic necroinflammation and worsening portal hypertension in patients with cirrhosis. We aimed to evaluate the associations between degree of alcohol use and clinical liver‐related outcomes according to etiology of cirrhosis. In this retrospective cohort analysis, 44,349 U.S.

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