A Dual‐Filtration System for Single‐Cell Sequencing of Circulating Tumor Cells and Clusters in HCC

Vincent L. Chen, Qianhui Huang, Ramdane Harouaka, Yuheng Du, Anna S. Lok, Neehar D. Parikh, Lana X. Garmire, Max S. Wicha – 22 January 2022 – Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide. Identification and sequencing of circulating tumor (CT) cells and clusters may allow for noninvasive molecular characterization of HCC, which is an unmet need, as many patients with HCC do not undergo biopsy. We evaluated CT cells and clusters, collected using a dual‐filtration system in patients with HCC.

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