Effect of alanine on D‐galactosamine‐induced acute liver failure in rats
K Maezono, K Mawatari, K Kajiwara, A Shinkai, T Maki – 1 November 1996 – The effect of high‐dose alanine on survival and liver function in rats with acute liver failure caused by a lethal dose of D‐galactosamine (D‐gal) was studied. Greater than 90% of control animals died within 5 days after D‐gal injection, but alanine significantly decreased mortality, even when treatment was started at 12 hours after D‐gal injection. Alanyl‐glutamine had a slight effect, but glucose produced no improvement.