Anti‐selectin therapy against hepatic ischemia‐reperfusion injury

Hartmut Jaeschke – 30 December 2003 – Evidence shows that leukocyte recruitment into inflamed liver sinusoids does not require selectins, with one notable exception: ischemia‐reperfusion (I/R). We used intravital microscopy to directly visualize the liver microcirculation during I/R and localized endotoxemia (liver superfused with lipopolysaccharide). General anti‐selectin therapy (fucoidan) or anti‐adhesion therapy with an antithrombin inhibitor (hirudin) was also used.

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