Charles J. Imber, Shawn D. St. Peter, Inigo Lopez, Lynden Guiver, Peter J. Friend – 30 December 2003 – A strong association exists between the presence of steatosis in a donor liver for transplantation and the development of primary nonfunction in the recipient. Despite this, appraisal of the donor remains one of the least scientific aspects of the transplantation process, and many centers base their practice on subjective opinion, rather than objective data.

Ryutaro Hirose – 30 December 2003

Robert S. Brown, K. Shiva Kumar, Mark W. Russo, Milan Kinkhabwala, Dianne L. Rudow, Patricia Harren, Steven Lobritto, Jean C. Emond – 30 December 2003 – The Model for End‐Stage Liver Disease (MELD) has been proposed as a replacement for the Child‐Turcotte‐Pugh (CTP) classification to stratify patients for prioritization for orthotopic liver transplantation (OLT).

A. Joseph Tector, Jonathan A. Fridell, Nahel Elias, Taichi Watanabe, Julie Salazar, Doris Greinke, Peter Metrakos, Jean I. Tchervenkov – 30 December 2003 – Discordant liver xenotransplantation is a poorly explored entity. Data from the few large animal studies of hepatic xenotransplantation suggest that severe hemorrhage is encountered. The purpose of the studies described here is to characterize the nature of the hemorrhage that accompanies liver xenotransplantation. Canine livers were transplanted into porcine recipients, and lethal hemorrhage was encountered.

Giorgio Ballardini, Emilio De Raffele, Paolo Groff, Paulette Bioulac‐Sage, Alberto Grassi, Sabrina Ghetti, Micaela Susca, Mario Strazzabosco, Roberto Bellusci, Rosa Maria Iemmolo, Gianluca Grazi, Daniela Zauli, Antonino Cavallari, Francesco Bianco Bianchi – 30 December 2003 – Pathogenic mechanisms and dynamics of hepatitis C virus (HCV) reinfection in orthotopic liver transplantation (OLT) are poorly defined.

Hugo R. Rosen, Jonathan M. Schwartz – 30 December 2003 – Recurrence of hepatitis C virus (HCV) infection after liver transplantation is almost universal and usually leads to chronic hepatitis with different degrees of severity. The pathogenic mechanisms underlying the variable outcome of HCV infection recurrence are not well defined, but recent data suggest that the dynamics of HCV quasispecies may be involved.

Jorge Rakela, Hugo Vargas, Juan Arenas – 30 December 2003 – Background: Wilson's disease, heralded by severe hepatic insufficiency, is a rare disorder for which emergency liver transplantation is considered to be the only effective therapy. Aims: To report the features of Wilson's disease with severe hepatic insufficiency in a series of 17 patients and, during the second period of the study, to assess the efficacy of a policy consisting of early administration of D‐penicillamine. Patients: Seventeen consecutive patients with Wilson's disease were studied.

David R. Nelson, Consuelo Soldevila‐Pico, Alan Reed, Manal F. Abdelmalek, Alan W. Hemming, Willem J. van der Werf, Richard Howard, Gary L. Davis – 30 December 2003 – The pathogenesis of hepatitis C virus (HCV) recurrence after liver transplantation (LT) is poorly understood, but the cellular immune response is likely to have a major role. Daclizumab, an interleukin‐2 receptor (IL‐2R) antibody that blunts T‐cell activation, leading to a decreased risk for cellular rejection, is used frequently in transplant recipients.

Lars E. Schmidt, Vibeke Rømming Sørensen, Lars Bo Svendsen, Bent A. Hansen, Fin Stolze Larsen – 30 December 2003 – The aim of this pilot study is to evaluate the circulatory safety of treatment with the molecular adsorbents recirculating system (MARS) by determining the effect on systemic hemodynamics of a single MARS treatment in patients with acute‐on‐chronic liver failure (AOCLF). In eight patients admitted with AOCLF, a single 10‐hour MARS treatment was performed. Systemic hemodynamic variables were determined before and during treatment.

Thomas P. Beresford – 30 December 2003 – Key Points 1Mental status changes are often the earliest indication of an untoward complication after transplantation.