Glycine Prevents Apoptosis of Rat Sinusoidal Endothelial Cells Caused by Deprivation of Vascular Endothelial Growth Factor

Yan‐jun Zhang, Kenichi Ikejima, Hajime Honda, Tsuneo Kitamura, Yoshiyuki Takei, Nobuhiro Sato – 30 December 2003 – Apoptosis of sinusoidal endothelial cells (SECs) is one of the initial events in the development of ischemia‐reperfusion injury of the liver. Glycine has been shown to diminish ischemia‐reperfusion injury in the liver and improve graft survival in the rat liver transplantation model. Here, we investigated the effect of glycine on apoptosis of primary cultured rat SECs induced by vascular endothelial growth factor (VEGF) deprivation.

Molecular mechanisms of tumor necrosis factor α–stimulated leukocyte recruitment into the murine hepatic circulation

Alison Fox‐Robichaud, Paul Kubes – 30 December 2003 – To date, much of the adhesion work in the liver has been restricted to sinusoids and postsinusoidal venules. However, selectins have been localized on the portal (presinusoidal) venules and these vessels have been shown to be important in metastasis of tumors. The purpose of this study was to characterize the leukocyte‐endothelial interactions within the 3 compartments of the hepatic microvasculature under baseline conditions and in response to tumor necrosis factor α (TNF‐α).

Glutathione, lactobionate, and histidine: cryptic inhibitors of matrix metalloproteinases contained in university of wisconsin and histidine/tryptophan/ketoglutarate liver preservation solutions

Gundumi Aravinda Upadhya, Steven M. Strasberg – 30 December 2003 – UW solution and HTK solution are both used for cold preservation of liver allografts. Although they are about equally effective, their compositions are very different, and they were formulated using different rationales. The authors recently showed an important role for MMPs in liver preservation injury and consequently postulated that these preservation solutions contain cryptic inhibitors of MMP activity. To determine this possibility, the ability of these solutions to inhibit MMP activity was studied.

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