Deregulation of iron homeostasis and cold‐preservation injury to rat liver stored in University of Wisconsin solution

Samuel Wyllie, Philip Seu, Feng Q. Gao, John A. Goss – 30 December 2003 – Very little is known about iron metabolism and the mediators of iron metabolism in liver subjected to cold storage before transplantation. Therefore, in this study, we investigated the effect of cold storage on iron homeostasis in the rat liver. When livers were stored at 4°C in University of Wisconsin solution for up to 6 and 24 hours, significant increases occurred in the labile iron pool, ferritin protein, and heme oxygenase activity.

Effect of molecular adsorbent recirculating system in hepatitis C virus‐related intractable pruritus

Cataldo Doria, Lucio Mandalá, Jan Smith, Claudio H. Vitale, Augusto Lauro, Salvatore Gruttadauria, Ignazio R. Marino, Carlo Scotti Foglieni, Mario Magnone, Victor L. Scott – 30 December 2003 – Intractable pruritus is more common in cholestatic liver diseases and may be the presenting symptom and/or major complaint of hepatitis C and/or hepatitic C virus—related cirrhosis. From September 2000 to May 2002, three patients affected by intractable pruritus secondary to hepatitis C cirrhosis that failed medical treatment were treated with a molecular adsorbent recirculating system (MARS).

Successful treatment of fibrosing cholestatic hepatitis using adefovir dipivoxil in a patient with cirrhosis and renal insufficiency

Hans L. Tillmann, C. Thomas Bock, Jörg S. Bleck, Jens Rosenau, Klaus H. W. Böker, Hannelore Barg‐Hock, Thomas Becker, Christian Trautwein, Jürgen Klempnauer, Peer Flemming, Michael P. Manns – 30 December 2003 – Fibrosing cholestatic hepatitis is a deleterious manifestation of hepatitis B virus infection in immunocompromised patients. Without treatment, this condition is usually fatal within weeks of onset. Liver retransplantation has not been successfully performed to date, and treatment intervention was generally unsuccessful before the advent of adefovir dipivoxil.

Socioeconomic status does not affect the outcome of liver transplantation

Hwan Y. Yoo, Violetta Galabova, David Edwin, Paul J. Thuluvath – 30 December 2003 – The outcome of liver transplantation is dependent on many factors. It was suggested that racial disparities in outcome may be related to differences in socioeconomic status (SES). In this retrospective study, we analyzed the effect of SES on graft and patient survival. Two hundred seventy‐six adult patients who underwent liver transplantation at our institution from July 1988 to June 2001 were included in the analysis.

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