Deregulation of iron homeostasis and cold‐preservation injury to rat liver stored in University of Wisconsin solution
Samuel Wyllie, Philip Seu, Feng Q. Gao, John A. Goss – 30 December 2003 – Very little is known about iron metabolism and the mediators of iron metabolism in liver subjected to cold storage before transplantation. Therefore, in this study, we investigated the effect of cold storage on iron homeostasis in the rat liver. When livers were stored at 4°C in University of Wisconsin solution for up to 6 and 24 hours, significant increases occurred in the labile iron pool, ferritin protein, and heme oxygenase activity.