Kwan Man, Chung‐Mau Lo, Terence Kin‐Wah Lee, Xian‐Liang Li, Irene Oi‐Lin Ng, Sheung‐Tat Fan – 30 December 2003 – The aim of this study is to identify the molecular mechanism of small‐for‐size graft injury through large‐scale expression measurement of intragraft gene profile by carrier DNA (cDNA) microarray screening in liver transplantation.
Ramón Rull, Oscar Vidal, Dulce Momblan, Francisco Xavier González, Miguel Angel López‐Boado, Jose Fuster, Luis Grande, Miguel Bruguera, Katiana Cabrer, Juan Carlos García‐Valdecasas – 30 December 2003 – The aim of this study was to evaluate the predictive value of different donor and recipient parameters that have been recognised previously as proven and to suggest prognostic factors for immediate liver function and final outcome after liver transplantation. We evaluated a total of 228 liver grafts transplanted in the last 3 years in our institution.
Gérald Longheval, Pierre Vereerstraeten, Philippe Thiry, Myriam Delhaye, Olivier le Moine, Jacques Devière, Nadine Bourgeois, Michael Adler – 30 December 2003 – The limited number of donor organs has placed a burden on the medical community to improve patient selection and timing of liver transplantation (LT). We aim to evaluate short‐ and long‐term survival of 124 consecutive patients with a diagnosis of nonbiliary cirrhosis. Seventeen clinical, biochemical, functional, and hemodynamic parameters were computed.
Dianne LaPointe Rudow, Mark W. Russo, Sylvia Hafliger, Jean C. Emond, Robert S. Brown – 30 December 2003 – The shortage of cadaver livers and improved outcomes in partial liver transplants has led to an increase in adult living donor liver transplantation (LDLT). Only a fraction of potential liver recipients have donors. The characteristics of candidates who have volunteers for living donation may be different than those without donors. We compared adult patients on the waiting list who had potential living donors with those who did not have living donors.
Nicholas N. Onaca, Marlon F. Levy, Edmund Q. Sanchez, Srinath Chinnakotla, Carlos G. Fasola, Mark J. Thomas, Jeffrey S. Weinstein, Natalie G. Murray, Robert M. Goldstein, Goran B. Klintmalm – 30 December 2003 – The Model for End‐Stage Liver Disease (MELD) score is now the criteria for allocation in liver transplantation for patients with chronic disease. Although the score has been effective in the prediction of mortality in patients awaiting liver transplantation, its abilities to predict posttransplantation outcome need study.
Yasuhiko Sugawara, Masatoshi Makuuchi, Hiroshi Imamura, Junichi Kaneko, Norihiro Kokudo – 30 December 2003 – The risk of outflow obstruction in extended right liver grafts remains a concern. We developed two procedures to minimize torsion in venous anastomosis and to achieve a short warm ischemic time of the graft. When there were no major short hepatic veins in the graft, a square‐shaped vein graft was used to make a single orifice using the middle and right hepatic veins in the graft.
Shawn D. St. Peter, Adyr A. Moss, David C. Mulligan – 30 December 2003 – In addition to efficacious immunosuppression for the benefit of organ transplantation, tacrolimus has diverse actions that result in amelioration of ischemia‐reperfusion injury. Knowledge is accumulating rapidly on the mechanisms through which tacrolimus exerts these cytoprotective effects, including alterations in microcirculation, free radical metabolism, calcium‐activated pathways, inflammatory cascades, mitochondrial stability, apoptosis, stress‐response proteins, and tissue recovery.
Shawn D. St. Peter, David J. Post, Manuel I. Rodriguez‐Davalos, David D. Douglas, Adyr A. Moss, David C. Mulligan – 30 December 2003 – The goal of this report is to evaluate in a prospective randomized fashion the effect of flushing hepatic allografts with tacrolimus before transplantation. A prospective, double‐blinded, randomized trial was performed. Twenty patients receiving orthotopic liver transplants from October 2000 to October 2001 were randomized into two groups.
Douglas W. Hanto, Annie H. Fecteau, Maria H. Alonso, John F. Valente, James F. Whiting – 30 December 2003 – ABO‐incompatible liver transplants (LTX) have been associated with a high risk of antibody‐mediated rejection, poor patient and graft survival, and a high risk of vascular thrombosis and ischemic bile duct complications.
Dharmesh Kapoor, Doris N. Redhead, Peter C. Hayes, David J. Webb, Rajiv Jalan – 30 December 2003 – An acute increase in portal pressure or reduction in portal inflow has been shown to decrease renal plasma flow (RPF). The aim of the study was to evaluate regional and systemic hemodynamics after acute occlusion of a transjugular intrahepatic portosystemic stent‐shunt (TIPSS) and study the effect of the same on plasma endothelin (ET‐1) levels in the systemic circulation, renal vein, and hepatic vein. Sixteen patients attending for portography after previous TIPSS placement were studied.