Distinct responsiveness to rifaximin in patients with hepatic encephalopathy depends on functional gut microbial species

Yoshimi Yukawa‐Muto, Tomonori Kamiya, Hideki Fujii, Hiroshi Mori, Atsushi Toyoda, Ikuya Sato, Yusuke Konishi, Akiyoshi Hirayama, Eiji Hara, Shinji Fukuda, Norifumi Kawada, Naoko Ohtani – 15 April 2022 – Hepatic encephalopathy (HE) is the neuropsychiatric complication of liver cirrhosis (LC). The influence of gut microbiota on HE pathogenesis has been suggested but not precisely elucidated. Here, we investigate how the gut microbial profile changed in patients with HE to clarify the functional gut microbial species associated with HE.

Tripartite motif‐containing protein 31 confers protection against nonalcoholic steatohepatitis by deactivating mitogen‐activated protein kinase kinase kinase 7

Min‐Xuan Xu, Jun Tan, Chen‐Xu Ge, Wei Dong, Li‐Ting Zhang, Lian‐Cai Zhu, Jun‐Jie Zhao, Long‐Yan Wang, Jin Liu, Hao Wei, Yan Sun, Xian‐Ling Dai, Qin Kuang, Yan‐Liang Li, Han Li, Jun‐Yan Liu, Lei Zou, Ran‐Ran Liang, Chu‐Feng Zhang, Juan Xu, Bo‐Chu Wang – 15 April 2022

Body fat composition determines outcomes before and after liver transplantation in patients with cirrhosis

Cornelius Engelmann, Niklas F. Aehling, Stefan Schob, Ines Nonnenmacher, Luise Handmann, Jane Macnaughtan, Adam Herber, Alexey Surov, Thorsten Kaiser, Timm Denecke, Rajiv Jalan, Daniel Seehofer, Michael Moche, Thomas Berg – 13 April 2022 – Cachexia occurs in late stages of liver cirrhosis, and a low‐fat mass is potentially associated with poor outcome. This study compared different computed tomography (CT)–derived fat parameters with respect to its prognostic impact on the development of complications and death before and after liver transplantation.

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