Christine Demeilliers, Emmanuel Jacquemin, Véronique Barbu, Martine Mergey, François Paye, Laura Fouassier, Nicolas Chignard, Chantal Housset, Nour‐Eddine Lomri – 20 April 2006 – Recent reports in patients with PFIC1 have indicated that a gene defect in ATP8B1 could cause deregulations in bile salt transporters through decreased expression and/or activity of FXR. This study aimed to: (1) define ATP8B1 expression in human hepatobiliary cell types, and (2) determine whether ATP8B1 defect affects gene expressions related to bile secretion in these cells.

Federico P. Gómez, Joan A. Barberà, Josep Roca, Felip Burgos, Concepción Gistau, Robert Rodríguez‐Roisin – 20 April 2006 – Enhanced pulmonary production of nitric oxide (NO) has been implicated in the pathogenesis of hepatopulmonary syndrome (HPS). NO inhibition with NG‐nitro‐L‐arginine methyl ester (L‐NAME) in both animals and humans with HPS has improved arterial hypoxemia. We assessed the role of enhanced NO production in the pathobiology of arterial deoxygenation in HPS and the potential therapeutic efficacy of selective pulmonary NO inhibition.

Ryan M. Taylor, Paula Bockenstedt, Grace L. Su, Jorge A. Marrero, Shawn M. Pellitier, Robert J. Fontana – 20 April 2006 – Thrombocytopenia is common among liver transplant candidates and recipients. The aim of our study was to determine the incidence and outcome of new‐onset immune‐mediated thrombocytopenic purpura (ITP) following liver transplantation at a single center.

Robert C. Verdonk, Carlijn I. Buis, Robert J. Porte, Eric J. van der Jagt, Abraham J. Limburg, Aad P. van den Berg, Maarten J.H. Slooff, Paul M.J.G. Peeters, Koert P. de Jong, Jan H. Kleibeuker, Elizabeth B. Haagsma – 20 April 2006 – We retrospectively studied the prevalence, presentation, results of treatment, and graft and patient survival of grafts developing an anastomotic biliary stricture (AS) in 531 adult liver transplantations performed between 1979 and 2003. Clinical and laboratory information was obtained from the hospital files, and radiological studies were re‐evaluated.

Michael B. Fallon – 20 April 2006

Mark Branda, Jack R. Wands – 20 April 2006

Gary L. Davis – 20 April 2006

Stephen A. Harrison – 20 April 2006

Gunda Millonig, Thomas Buratti, Ivo W. Graziadei, Hubert Schwaighofer, Dorothea Orth, Raimund Margreiter, Wolfgang Vogel – 20 April 2006 – After liver transplantation (LT), bactobilia occurs frequently in patients, leading in some cases to cholangitis and biliary sepsis. The present study is the first to investigate bactobilia after LT, and it gives an overview of predisposing factors for bactobilia, the microbial spectrum in the bile of LT patients, and the antibiotic susceptibility.

Wang Wei‐lin, Jin Jing, Zheng Shu‐sen, Wu Li‐hua, Liang Ting‐bo, Yu Song‐feng, Yan Sheng – 20 April 2006 – The aim of this study was to investigate whether the heterogeneity in tacrolimus dose requirement is associated with ABCB1 and CYP3A5 gene polymorphisms in Chinese liver transplant patients during the first month after transplantation. ABCB1 and CYP3A5 genotyping was performed using the polymerase chain reaction restriction sites polymorphism–based procedure in Chinese liver transplant recipients (n = 50) and their corresponding donors (n = 50).