Julien Crettaz, Pedro Berraondo, Itsaso Mauleón, Laura Ochoa, Vijay Shankar, Miguel Barajas, Nico van Rooijen, Stefan Kochanek, Cheng Qian, Jesús Prieto, Rubén Hernández‐Alcoceba, Gloria González‐Aseguinolaza – 29 August 2006 – Recombinant adenoviruses (Ad) are among the most extensively used vectors for liver gene transfer. One of the major limitations for the clinical application of these vectors is the inflammatory immune response associated with systemic administration of high dose of virus.

Carlos Guarner, José M. González‐Navajas, Elisabet Sánchez, Germán Soriando, Rubén Francés, Maite Chiva, Pedro Zapater, Susana Benlloch, Carlos Muñoz, Sonia Pascual, Joaquín Balanzó, Miguel Pérez‐Mateo, José Such – 29 August 2006 – Bacterial DNA (bactDNA) is present in blood and ascitic fluid (AF) in a third of patients with cirrhosis and ascites, but whether this phenomenon represents episodes of bacterial translocation (BT), strictly considered when culture of mesenteric lymph nodes (MLNs) are positive, remains unknown.

29 August 2006

Hyung Joon Yim, Munira Hussain, Ying Liu, Stephen N. Wong, Scott K. Fung, Anna S. F. Lok – 29 August 2006 – Multi‐drug resistant hepatitis B virus (HBV) has been reported in hepatitis B patients who received sequential antiviral therapy. In vitro studies showed that HBV constructs with mutations resistant to lamivudine and adefovir have marked reduction in sensitivity to combination of lamivudine and adefovir, whereas constructs with mutations resistant to either drug remain sensitive to the other drug.

Anaïs Vallet‐Pichard, Vincent Mallet, Stanislas Pol – 29 August 2006

Anneke Funk, Mouna Mhamdi, Heinz Hohenberg, Hans Will, Hueseyin Sirma – 29 August 2006 – Entry and intracellular transport of hepatitis B viruses have several unusual, largely unknown aspects. In this study, we explored the mode of virus entry using the duck hepatitis B virus (DHBV) and the primary hepatocyte infection model. Upon internalization, viral particles were enriched in an endosomal compartment, as revealed by biochemical and ultrastructural analysis. Virus‐containing vesicles harbored early endosome markers.

Gary L. Davis – 24 August 2006

Maureen M. J. Guichelaar, Rebecca Kendall, Michael Malinchoc, J. Eileen Hay – 24 August 2006 – Fracturing after liver transplantation (OLT) occurs due to the combination of preexisting low bone mineral density (BMD) and early posttransplant bone loss, the risk factors for which are poorly defined.

Sheung Tat Fan – 24 August 2006

Thomas D. Schiano, Michael Charlton, Zobair Younossi, Eithan Galun, Timothy Pruett, Ran Tur‐Kaspa, Rachel Eren, Shlomo Dagan, Neil Graham, Paulette V. Williams, John Andrews – 24 August 2006 – A randomized, double‐blind, dose‐escalation study evaluated the safety and efficacy of hepatitis C virus (HCV)‐AbXTL68, a neutralizing, high‐affinity, fully human, anti‐E2 monoclonal antibody, in 24 HCV‐positive patients undergoing liver transplantation.