Hepatic precursors derived from murine embryonic stem cells contribute to regeneration of injured liver

Jeonghoon Heo, Valentina M. Factor, Tania Uren, Yasushi Takahama, Ju‐Seog Lee, Marian Major, Stephen M. Feinstone, Snorri S. Thorgeirsson – 28 November 2006 – We established an efficient system for differentiation, expansion and isolation of hepatic progenitor cells from mouse embryonic stem (ES) cells and evaluated their capacity to repopulate injured liver.

Genomics and complex liver disease: Challenges and opportunities

Brian D. Juran, Konstantinos N. Lazaridis – 28 November 2006 – The concept of genetic susceptibility in the contribution to human disease is not new. What is new is the emerging ability of the field of genomics to detect, assess, and interpret genetic variation in the study of susceptibility to development of disease. Deciphering the human genome sequence and the publication of the human haplotype map are key elements of this effort.

Aquaporin‐1 and aquaporin‐2 urinary excretion in cirrhosis: Relationship with ascites and hepatorenal syndrome

Christina Esteva‐Font, Maria E. Baccaro, Patricia Fernández‐Llama, Laia Sans, Monica Guevara, Elisabet Ars, Wladimiro Jiménez, Vicente Arroyo, Jose A. Ballarín, Pere Ginès – 28 November 2006 – Several experimental models of cirrhosis have shown dysregulation of renal aquaporins in different phases of liver disease. We investigated the urinary excretion of both aquaporin‐1 and aquaporin‐2 in patients with cirrhosis at different stages of the disease.

Outcome of acute idiosyncratic drug‐induced liver injury: Long‐term follow‐up in a hepatotoxicity registry

Raúl J. Andrade, M. Isabel Lucena, Neil Kaplowitz, Beatriz García‐Muņoz, Yolanda Borraz, Ketevan Pachkoria, Miren García‐Cortés, M. Carmen Fernández, Gloria Pelaez, Luis Rodrigo, José A. Durán, Joan Costa, Ramón Planas, Anabel Barriocanal, Carlos Guarner, Manuel Romero‐Gomez, Teresa Muņoz‐Yagüe, Javier Salmerón, Ramón Hidalgo – 28 November 2006 – A chronic adverse reaction may occur in some instances of drug‐induced liver injury (DILI), even despite drug cessation.

Alpha‐fetoprotein and prognosis in acute liver failure

Frank V. Schiødt, George Ostapowicz, Natalie Murray, Raj Satyanarana, Atif Zaman, Santiago Munoz, William M. Lee – 28 November 2006 – Serum concentrations of alpha‐fetoprotein (AFP), variably elevated during liver injury, have been suggested to be of prognostic importance in acute liver failure (ALF), higher values being associated with improved outcome. Using a nephelometric assay, we measured AFP in sera obtained on admission from 206 patients prospectively enrolled in the US ALF Study, and on day 3 in 162 of these patients.

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