Murine liver plasmacytoid dendritic cells become potent immunostimulatory cells after Flt‐3 ligand expansion

T. Peter Kingham, Umer I. Chaudhry, George Plitas, Steven C. Katz, Jesse Raab, Ronald P. DeMatteo – 26 January 2007 – The liver has unique immunological properties. Although dendritic cells (DCs) are central mediators of immune regulation, little is known about liver DCs. Plasmacytoid DCs (pDCs) are a recently identified subtype of murine liver DC. We sought to define the function of freshly isolated murine liver pDCs.

Central venous pressure monitoring during living right donor hepatectomy

Claus U. Niemann, John Feiner, Matthias Behrends, Helge Eilers, Nancy L. Ascher, John P. Roberts – 26 January 2007 – Low central venous pressure (CVP) has been advocated during liver resection to reduce blood loss and transfusion requirements. As a consequence, CVP catheter placement has been considered essential for hepatic surgery, including living donor hepatectomies. We retrospectively analyzed whether intraoperative management without CVP monitoring influenced fluid administration, blood loss, and patient outcome.

Temporary silastic mesh closure for adult liver transplantation: A safe alternative for the difficult abdomen

Mubeen A. Jafri, Amit D. Tevar, Mark Lucia, Thav Thambi‐Pillai, Andreas Karachristos, Leslie Trumbull, Joseph F. Buell, Mark J. Thomas, Michael J. Hanaway, E. Steve Woodle, Steven M. Rudich – 26 January 2007 – Primary fascial closure is often difficult after adult orthotopic liver transplantation (OLT), complicated by donor‐to‐recipient graft size mismatch, post‐reperfusion hepatic edema, coagulopathy, or intestinal edema. Attempts at closing the abdomen under these circumstances can cause increase in intra‐abdominal pressures, resulting in significant complications, including graft loss.

Activation of LXRs prevents bile acid toxicity and cholestasis in female mice

Hirdesh Uppal, Simrat P.S. Saini, Antonio Moschetta, Ying Mu, Jie Zhou, Haibiao Gong, Yonggong Zhai, Songrong Ren, George K. Michalopoulos, David J. Mangelsdorf, Wen Xie – 26 January 2007 – Liver X receptors (LXRs) have been identified as sterol sensors that regulate cholesterol and lipid homeostasis and macrophage functions. In this study, we found that LXRs also affect sensitivity to bile acid toxicity and cholestasis.

The role of chrysin and the Ah receptor in induction of the human UGT1A1 gene in vitro and in transgenic UGT1 mice

Jessica A. Bonzo, Alain Bélanger, Robert H. Tukey – 26 January 2007 – The flavonoid chrysin is an important dietary substance and induces UGT1A1 protein expression in cell culture. As a representative of the class of dietary flavonoids, clinical investigations have been considered as a means of inducing hepatic UGT1A1 expression. We demonstrate the necessity of a xenobiotic response element (XRE) in support of chrysin induction of UGT1A1 in the human hepatoma cell line HepG2.

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