Heike Varnholt, Uta Drebber, Falko Schulze, Inga Wedemeyer, Peter Schirmacher, Hans‐Peter Dienes, Margarete Odenthal – 19 December 2007 – MicroRNAs are small noncoding RNAs that regulate gene expression by targeting messenger RNAs (mRNAs) through translational repression or RNA degradation. Many fundamental biological processes are modulated by microRNAs, and an important role for microRNAs in carcinogenesis is emerging.

Alphonse E. Sirica, Zichen Zhang, Guan‐Hua Lai, Toru Asano, Xue‐Ning Shen, Deanna J. Ward, Arvind Mahatme, Jennifer L. DeWitt – 14 December 2007 – Intrahepatic cholangiocarcinoma typically presents in an advanced stage in which treatment options are limited. In an effort to recapitulate key biological and clinical features of the progressive disease, we established a novel rat model based on bile duct inoculation of rat cholangiocyte cell lines in different stages of tumor progression.

Jorge Gracia‐Sancho, Bàrbara Laviña, Aina Rodríguez‐Vilarrupla, Héctor García‐Calderó, Mercedes Fernández, Jaume Bosch, Joan‐Carles García‐Pagán – 10 December 2007 – In cirrhotic livers, decreased nitric oxide (NO) bioavailability is a major factor increasing intrahepatic vascular tone. In several vascular disorders, an increase in superoxide (O2−) has been shown to contribute to reduced NO bioavailability through its reaction with NO to form peroxynitrite. This study was aimed to test the hypothesis that, in cirrhotic livers, increased O2−, by reacting with NO, reduces NO bioavailability.

Harel Dahari, Alan S. Perelson – 28 November 2007

Sukru Emre, Ronen Arnon, Emil Cohen, Raffaella A. Morotti, Dmitriy Vaysman, Benjamin L. Shneider – 28 November 2007 – Congenital absence of portal vein and extrahepatic portocaval shunt, also referred to as an Abernethy type 1, is a rare malformation of the mesenteric vasculature. A 9‐year‐old girl presented with dyspnea on exertion and orthodeoxia. A diagnosis of an Abernethy malformation type 1b and hepatopulmonary syndrome (HPS) was made, and she underwent auxiliary partial orthotopic liver transplantation (APOLT). Symptoms and signs of HPS resolved 2 months after the operation.

John A. Goss, Neal R. Barshes, W. Kenneth Washburn – 28 November 2007

Marwan Ghabril, Justin Nguyen, David Kramer, Trina Genco, Martin Mai, Barry G. Rosser – 28 November 2007 – The liver's role as the largest organ of metabolism and the unique and often critical function of liver‐specific enzyme pathways imply a greater risk to the recipient of acquiring a donor metabolic disease with liver transplants versus other solid organ transplants. With clinical consequences rarely reported, the frequency of solid organ transplant transfer of metabolic disease is not known.

Ian Homer Y. Cua, Jacob George – 28 November 2007

Anna Wieckowska, Arthur J. McCullough, Ariel E. Feldstein – 28 November 2007

José A. Solís‐Herruzo, Inmaculada García‐Ruiz – 28 November 2007