Hisashi Ueta, Changde Shi, Nobutomo Miyanari, Xue‐Dong Xu, Shu Zhou, Masaki Yamashita, Taichi Ezaki, Kenjiro Matsuno – 25 January 2008 – Donor dendritic cell (DC) migration and allosensitization in host secondary lymphoid organs after liver transplantation are ill defined. We used rat models to investigate graft‐derived cells and intrahost allosensitization.
Daan van Poll, Biju Parekkadan, Cheul H. Cho, François Berthiaume, Yaakov Nahmias, Arno W. Tilles, Martin L. Yarmush – 24 January 2008 – Orthotopic liver transplantation is the only proven effective treatment for fulminant hepatic failure (FHF), but its use is limited because of organ donor shortage, associated high costs, and the requirement for lifelong immunosuppression. FHF is usually accompanied by massive hepatocellular death with compensatory liver regeneration that fails to meet the cellular losses.
Xandra Volkmann, Matthias Anstaett, Johannes Hadem, Penelope Stiefel, Matthias J. Bahr, Frank Lehner, Michael P. Manns, Klaus Schulze‐Osthoff, Heike Bantel – 24 January 2008 – Acute liver failure (ALF) has various causes and is characterized by rapid hepatocyte dysfunction with development of encephalopathy in the absence of preexisting liver disease. Whereas most patients require liver transplantation to prevent the high mortality, some patients recover spontaneously and show complete liver regeneration.
Reiichiro Kuwahara, Alexander V. Kofman, Charles S. Landis, E. Scott Swenson, Els Barendswaard, Neil D. Theise – 21 January 2008 – Label retention assays remain the state‐of‐the‐art approach to identify the location of intraorgan epithelial stem cell niches, in situ and in vivo. They are commonly used in organs with rapid cell turnover but have not been applied to the liver, where cell turnover is very slow.
Nathan A. Johnson, David W. Walton, Toos Sachinwalla, Campbell H. Thompson, Kate Smith, Patricia A. Ruell, Stephen R. Stannard, Jacob George – 21 January 2008 – Nonalcoholic fatty liver is frequently observed in obese individuals, yet the factors that predict its development and progression to liver disease are poorly understood. We proposed that proton magnetic resonance spectroscopy (1H‐MRS) might allow noninvasive assessment of hepatic lipid composition.
Nissa Erickson, Sujit Kumar Mohanty, Pranavkumar Shivakumar, Gregg Sabla, Ranajit Chakraborty, Jorge A. Bezerra – 21 January 2008 – Biliary atresia is a fibro‐inflammatory cholangiopathy that obstructs the extrahepatic bile ducts in young infants. Although the pathogenesis of the disease is undefined, studies in livers from affected children and neonatal mice with experimental biliary atresia have shown increased expression of proapoptosis molecules. Therefore, we hypothesized that apoptosis is a significant mechanism of injury to duct epithelium.
Xinping Tan, Youzhong Yuan, Gang Zeng, Udayan Apte, Michael D. Thompson, Benjamin Cieply, Donna B. Stolz, George K. Michalopoulos, Klaus H. Kaestner, Satdarshan P.S. Monga – 21 January 2008 – β‐Catenin, the central component of the canonical Wnt pathway, plays important roles in the processes of liver regeneration, growth, and cancer. Previously, we identified temporal expression of β‐catenin during liver development.
Yongke Lu, Jian Zhuge, Xiaodong Wang, Jingxiang Bai, Arthur I. Cederbaum – 21 January 2008 – Cytochrome P450 2E1 (CYP2E1) is suggested to play a role in alcoholic liver disease, which includes alcoholic fatty liver, alcoholic hepatitis, and alcoholic cirrhosis. In this study, we investigated whether CYP2E1 plays a role in experimental alcoholic fatty liver in an oral ethanol‐feeding model. After 4 weeks of ethanol feeding, macrovesicular fat accumulation and accumulation of triglyceride in liver were observed in wild‐type mice but not in CYP2E1‐knockout mice.
Roman E. Perri, Michael V. Chiorean, Jeff L. Fidler, Joel G. Fletcher, Jayant A. Talwalkar, Linda Stadheim, Nilay D. Shah, Patrick S. Kamath – 21 January 2008 – Patients with cirrhosis require endoscopic screening for large esophageal varices. The aims of this study were to determine the cost‐effectiveness and patient preferences of a strategy employing abdominal computerized tomography (CT) as the initial screening test for identifying large esophageal varices. In a prospective evaluation,102 patients underwent both CT and endoscopic screening for gastroesophageal varices.
Clifford S. Guy, Sherri L. Rankin, Jinguo Wang, Tomasz I. Michalak – 21 January 2008 – The liver displays unique immunological properties including the ability to remove aberrant cells and pathogens and to induce peripheral immunotolerance. We have previously demonstrated that hepatocytes can cause cell death by a CD95 ligand–mediated mechanism. Here, we provide evidence that hepatocytes can kill other cells via a perforin‐dependent pathway.