Pretransplant lymphocyte count predicts the incidence of infection during the first two years after liver transplantation

Mario Fernández‐Ruiz, Francisco López‐Medrano, Eva María Romo, Luis María Allende, Juan Carlos Meneu, Yiliam Fundora‐Suárez, Rafael San‐Juan, Manuel Lizasoain, Estela Paz‐Artal, Jose María Aguado – 29 September 2009 – Patients with end‐stage liver disease (ESLD) show a low absolute number of peripheral blood lymphocyte subpopulations (PBLSs). We investigated if the baseline PBLS could categorize orthotopic liver transplantation (OLT) recipients into groups at high or low risk for infection after transplantation.

Liver transplantation cost in the model for end‐stage liver disease era: Looking beyond the transplant admission

Paula Buchanan, Nino Dzebisashvili, Krista L. Lentine, David A. Axelrod, Mark A. Schnitzler, Paolo R. Salvalaggio – 29 September 2009 – We examined the relationship between the total cost incurred by liver transplantation (LT) recipients and their Model for End‐Stage Liver Disease (MELD) score at the time of transplant. We used a novel database linking billing claims from a large private payer with the Organ Procurement and Transplantation Network registry. Included were adults who underwent LT from March 2002 through August 2007 (n = 990).

Long‐term management after liver transplantation: Primary care physician versus hepatologist

J. Christie Heller, Allan V. Prochazka, Gregory T. Everson, Lisa M. Forman – 29 September 2009 – As long‐term survival after liver transplantation increases, metabolic complications are becoming increasingly prevalent. Given concerns about which group of providers should be managing liver recipients and how well metabolic complications are managed, we administered a postal survey to 280 transplant hepatologists to determine attitudes, perceptions, and practice patterns in the management of metabolic complications after transplantation. The response rate was 68.2%.

Preconditioning, organ preservation, and postconditioning to prevent ischemia‐reperfusion injury to the liver

Olivier de Rougemont, Kuno Lehmann, Pierre‐Alain Clavien – 29 September 2009 – Ischemia and reperfusion lead to injury of the liver. Ischemia‐reperfusion injury is inevitable in liver transplantation and trauma and, to a great extent, in liver resection. This article gives an overview of the mechanisms involved in this type of injury and summarizes protective and treatment strategies in clinical use today. Intervention is possible at different time points: during harvesting, during the period of preservation, and during implantation.

Plasma disappearance rate of indocyanine green: A tool to evaluate early graft outcome after liver transplantation

Eric Levesque, Faouzi Saliba, Sonia Benhamida, Philippe Ichaï, Daniel Azoulay, René Adam, Denis Castaing, Didier Samuel – 29 September 2009 – Indocyanine green clearance (Cl‐ICG) has been used to assess liver function and hepatic blood flow mainly before and after hepatic surgery. Cl‐ICG (invasive method) has been reported to be a good marker of early graft function after liver transplantation (LT).

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