Randa Elsheikh, Hoang Thuy Tien, Abdelrahman M. Makram, Nguyen Thanh Van, Trang Thi Bich Le, Tamilarasy Vasanthakumaran, Nguyen Tien Huy – 20 July 2022 – Since April 2022, the world has been witnessing a rapidly spreading outbreak of acute hepatitis of unknown origin in children < 16 years old that has affected several countries around the world. Most of the cases have presented with the clinical picture of severe hepatitis that has led to resorting to liver transplantation in several cases.

Kwang Yoon Kim, Kyung‐Won Hong, Bom Taeck Kim – 20 July 2022

Dong Hyun Sinn, Danbee Kang, Eliseo Guallar, Juhee Cho, Geum‐Youn Gwak – 20 July 2022

Shikai Hu, Catherine Cao, Minakshi Poddar, Evan Delgado, Sucha Singh, Anya Singh‐Varma, Donna Beer Stolz, Aaron Bell, Satdarshan P. Monga – 20 July 2022

Stephanie S. Maldonado, Joshua Grab, Connie W. Wang, Heather Huddleston, Marcelle Cedars, Monika Sarkar – 20 July 2022 – Polycystic ovary syndrome (PCOS) occurs in approximately 10% of all reproductive‐age women, with over 50% of these patients having imaging‐confirmed nonalcoholic fatty liver disease (NAFLD). Whether PCOS increases the risk for more clinically relevant disease, such as nonalcoholic steatohepatitis (NASH), is unclear. Such findings are relevant to prognosticating risk of progressive liver disease in the growing population of young adults with NAFLD.

Junwei Zhang, Yiyao Xu, Xin Lu, Haitao Zhao – 20 July 2022

Cong Ning, Shi‐Tao Jiang, Xin‐Ting Sang – 20 July 2022

Andrew M. Moon, Hannah P. Kim, Sarah Cook, Renee T. Blanchard, Katarina L. Haley, Adam Jacks, Jennifer S. Shafer, Michael W. Fried – 20 July 2022 – Hepatic encephalopathy (HE) is a complication of cirrhosis that benefits from early diagnosis and treatment. We aimed to characterize speech patterns of individuals with HE to investigate its potential to diagnose and monitor HE. This was a single‐center prospective cohort study that included participants with cirrhosis with HE (minimal HE [MHE] and overt HE [OHE]), cirrhosis without HE, and participants without liver disease.

Ning Li, Yilie Liao, Haipeng Huang, Suneng Fu – 20 July 2022 – Both iron overload and iron deficiency have been reported in obesity and metabolic syndromes. Due to the presence of multiple intracellular iron pools and the dynamic nature of iron mobilization and use, the actual status and contribution of free and metabolically active iron toward metabolic syndrome remain to be established. The discovery of nuclear receptor coactivator 4 (NCOA4) as a ferritinophagy receptor provides an opening to address the connection between iron and metabolic diseases.

Whitney S. Thompson, Jacob R. Greenmyer, Brendan C. Lanpher, Jane E. Brumbaugh, Ellen M. Bendel‐Stenzel, David P. Dimmock, Charlotte A. Hobbs, Samar H. Ibrahim, Amber N. Hildreth – 20 July 2022