Real‐time tissue elastography in the assessment of liver stiffness
Giovanna Ferraioli, Raffaella Lissandrin, Carlo Filice – 22 December 2012
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Mark J. Czaja – 22 December 2012
Chronic hepatitis C virus (HCV) disease burden and cost in the United States
Homie Razavi, Antoine C. ElKhoury, Elamin Elbasha, Chris Estes, Ken Pasini, Thierry Poynard, Ritesh Kumar – 22 December 2012 – Hepatitis C virus (HCV) infection is a leading cause of cirrhosis, hepatocellular carcinoma, and liver transplantation. A better understanding of HCV disease progression and the associated cost can help the medical community manage HCV and develop treatment strategies in light of the emergence of several potent anti‐HCV therapies. A system dynamic model with 36 cohorts was used to provide maximum flexibility and improved forecasting.
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Yoichi Hiasa, Hironori Ochi, Masashi Hirooka – 22 December 2012
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Hiroyuki Tsuchiya, Kentaro Kogure, Goshi Shiota – 22 December 2012
Retinoids counteract insulin resistance and liver steatosis: What's the potential mechanism?
Nadia Panera, Sara Ceccarelli, Cristiano Stefanis, Valerio Nobili, Anna Alisi – 22 December 2012
Association of γ‐glutamyl transferase (GGT) activity with treatment and clinical outcomes in chronic hepatitis C (HCV)
James E. Everhart, Elizabeth C. Wright – 19 December 2012 – Increased γ‐glutamyl transferase (GGT) activity is associated with liver injury and with mortality in the general population. Less is known about its association with chronic hepatitis C (HCV) outcomes. We examined GGT as a predictor of both virological response to treatment and long‐term clinical outcomes in the Hepatitis C Anti‐viral Treatment Against Cirrhosis Trial (HALT‐C).
A novel interaction of nucleophosmin with BCL2‐associated X protein regulating death evasion and drug sensitivity in human hepatoma cells
Shao‐Jung Lo, Li‐Ching Fan, Yow‐Fu Tsai, Kuo‐Yang Lin, Hsiao‐Ling Huang, Tong‐Hong Wang, Hsuan Liu, Tse‐Chin Chen, Shiu‐Fen Huang, Chee‐Jen Chang, Yu‐Jr Lin, Benjamin Yat‐Ming Yung, Sen‐Yung Hsieh – 19 December 2012 – Death evasion is crucial for both carcinogenesis and resistance to anticancer therapies. Recently, we identified nucleophosmin (NPM) as a key factor counteracting death stimuli in human hepatocellular carcinoma (HCC) cells. Here we report the identification of a novel NPM‐BCL2‐associated X protein (BAX) pathway orchestrating death evasion in human HCC cells.
Characterization of the regulation and function of zinc‐dependent histone deacetylases during rodent liver regeneration
Jiansheng Huang, Emily Barr, David A. Rudnick – 19 December 2012 – The studies reported here were undertaken to define the regulation and functional importance of zinc‐dependent histone deacetylase (Zn‐HDAC) activity during liver regeneration using the mouse partial hepatectomy (PH) model. The results showed that hepatic HDAC activity was significantly increased in nuclear and cytoplasmic fractions following PH.
Argonaute2 promotes tumor metastasis by way of up‐regulating focal adhesion kinase expression in hepatocellular carcinoma
Na Cheng, Yandong Li, Ze‐Guang Han – 19 December 2012 – Hepatocellular carcinoma (HCC) is one of the most common cancers and shows a propensity to metastasize and infiltrate adjacent and more distant tissues. However, the mechanisms that contribute to tumor metastasis remain unclear. Here we evaluate the effect of Argonaute2 (Ago2), a member of the Ago gene family that plays a role in short interfering RNA‐mediated gene silencing, on HCC tumorigenesis, and metastasis. We found that Ago2 was frequently up‐regulated in HCC specimens compared to that in corresponding adjacent nontumor liver.