Single‐center experience and long‐term outcomes of duct‐to‐duct biliary reconstruction in infantile living donor liver transplantation

Hidekazu Yamamoto, Shintaro Hayashida, Katsuhiro Asonuma, Masaki Honda, Hiroko Suda, Takahiro Murokawa, Yuki Ohya, Kwang‐Jong Lee, Takayuki Takeichi, Yukihiro Inomata – 10 January 2014 – The indications for duct‐to‐duct (DD) biliary reconstruction in living donor liver transplantation (LDLT) for small children are still controversial. In this study, the feasibility of DD biliary reconstruction versus Roux‐en‐Y (RY) biliary reconstruction was investigated in terms of long‐term outcomes.

Additive effect of pretransplant obesity, diabetes, and cardiovascular risk factors on outcomes after liver transplantation

Anna J. Dare, Lindsay D. Plank, Anthony R. J. Phillips, Edward J. Gane, Barry Harrison, David Orr, Yannan Jiang, Adam S. J. R. Bartlett – 7 January 2014 – The effects of pretransplant obesity, diabetes mellitus (DM), coronary artery disease (CAD), and hypertension (HTN) on outcomes after liver transplantation (LT) are controversial. Questions have also been raised about the appropriateness of the body mass index (BMI) for assessing obesity in patients with end‐stage liver disease. Both issues have implications for organ allocation in LT.

Insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) is an important protumorigenic factor in hepatocellular carcinoma

Tony Gutschner, Monika Hämmerle, Nikolaos Pazaitis, Nadine Bley, Evgenij Fiskin, Hannah Uckelmann, Andreas Heim, Matthias Groβ, Nina Hofmann, Robert Geffers, Britta Skawran, Thomas Longerich, Kai Breuhahn, Peter Schirmacher, Britta Mühleck, Stefan Hüttelmaier, Sven Diederichs – 7 January 2014 – Hepatocarcinogenesis is a stepwise process. It involves several genetic and epigenetic alterations, e.g., loss of tumor suppressor gene expression (TP53, PTEN, RB) as well as activation of oncogenes (c‐MYC, MET, BRAF, RAS).

Liver biopsy–related infection in liver transplant recipients: A current matter of concern?

Cristina López Sánchez, Oscar Len, Joan Gavalda, Itxarone Bilbao, Lluis Castells, Maria Arantzazu Gelabert, Helena Allende, Albert Pahissa – 7 January 2014 – Data from published studies regarding risk factors for liver biopsy (LB)–related infectious complications in liver transplant recipients are inconsistent. We carried out a retrospective cohort study analyzing consecutive LBs for orthotopic liver transplant patients at a tertiary hospital (2001‐2011): there were 667 LB procedures (575 percutaneous procedures and 92 transjugular procedures) in 286 liver transplant recipients.

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