Next‐generation sequencing sheds light on the natural history of hepatitis C infection in patients who fail treatment

Tamer Abdelrahman, Joseph Hughes, Janice Main, John McLauchlan, Mark Thursz, Emma Thomson – 2 May 2014 – High rates of sexually transmitted infection and reinfection with hepatitis C virus (HCV) have recently been reported in human immunodeficiency virus (HIV)‐infected men who have sex with men and reinfection has also been described in monoinfected injecting drug users. The diagnosis of reinfection has traditionally been based on direct Sanger sequencing of samples pre‐ and posttreatment, but not on more sensitive deep sequencing techniques.

Tuberculosis in liver transplant recipients: Experience of a South Indian liver transplant center

Arikichenin Olithselvan, Srinivas Rajagopala, Mukul Vij, Vivekanandan Shanmugam, Naresh Shanmugam, Mohammed Rela – 30 April 2014 – Tuberculosis (TB) is a serious disease for liver transplant recipients (LTRs). Data on post–liver transplant TB from high‐burden countries are scant. The aims of this study were to describe the prevalence of TB in LTRs from a high‐prevalence area and to analyze the risk factors for the development of post–liver transplant TB. We performed a retrospective review of our database and a case‐control study of identified cases with TB and age‐matched LTRs without TB.

Evaluation of the pediatric patient for liver transplantation: 2014 practice guideline by the american association for the study of liver diseases, american society of transplantation and the north american society for pediatric gastroenterology, hepatolo

Combined hepatocellular‐cholangiocarcinoma: A population‐level analysis of an uncommon primary liver tumor

Mattia Garancini, Paolo Goffredo, Fabio Pagni, Fabrizio Romano, Sanziana Roman, Julie Ann Sosa, Vittorio Giardini – 29 April 2014 – Combined hepatocellular‐cholangiocarcinoma (cHCC‐CC) is a rare primary liver cancer. Our aims were to analyze the demographic, clinical, and pathological characteristics of cHCC‐CC at a population level and to investigate the effects of these features as well as different management strategies on the prognosis. The Surveillance, Epidemiology, and End Results (SEER) database was analyzed for 1988‐2009.

Comparative effectiveness of liver transplant strategies for end‐stage liver disease patients on renal replacement therapy

Yaojen Chang, Lorenzo Gallon, Colleen Jay, Kirti Shetty, Bing Ho, Josh Levitsky, Talia Baker, Daniela Ladner, John Friedewald, Michael Abecassis, Gordon Hazen, Anton I. Skaro – 29 April 2014 – There are complex risk‐benefit tradeoffs with different transplantation strategies for end‐stage liver disease patients on renal support.

Subscribe to