Causes and consequences of portal vein thrombosis in 1,243 patients with cirrhosis: Results of a longitudinal study

Filipe Nery, Sylvie Chevret, Bertrand Condat, Emmanuelle de Raucourt, Larbi Boudaoud, Pierre‐Emmanuel Rautou, Aurelie Plessier, Dominique Roulot, Cendrine Chaffaut, Valerie Bourcier, Jean‐Claude Trinchet, Dominique‐Charles Valla, on behalf of Groupe d'Etude et de Traitement du Carcinome Hépatocellulaire – 6 October 2014 – In cirrhosis, portal vein thrombosis (PVT) could be a cause or a consequence of the progression of liver disease.

Local allograft irradiation as an adjunct for treating severe resistant rejection after liver transplantation in adults

Rajesh Ramanathan, Amit Sharma, Matthew Kaspar, Martha Behnke, Shiyu Song, R. Todd Stravitz, Adrian Cotterell, Marc Posner, Robert A. Fisher – 6 October 2014 – Acute rejection after liver transplantation occurs in one‐third of all recipients and can be managed with conventional rejection therapy in the majority of cases. In rare instances, patients with severe acute rejection may be refractory to or have contraindications for conventional therapies.

Treatment of PD‐1−/− mice with amodiaquine and anti‐CTLA4 leads to liver injury similar to idiosyncratic liver injury in patients

Imir G. Metushi, M. Anthony Hayes, Jack Uetrecht – 6 October 2014 – The mechanism of idiosyncratic drug‐induced liver injury (IDILI) remains poorly understood, to a large degree because of the lack of a valid animal model. Recently, we reported an animal model in which treatment of female C57BL/6 mice with amodiaquine (AQ) resulted in mild liver injury with a delayed onset and resolution despite continued treatment. Such adaptation is a common outcome in the IDILI caused by drugs that can cause liver failure.

Association between anesthesiologist experience and mortality after orthotopic liver transplantation

Ira Hofer, John Spivack, Miguel Yaport, Jeron Zerillo, David L. Reich, David Wax, Samuel DeMaria – 4 October 2014 – The anesthesiologist has been recognized as an integral member of the liver transplant team, and previous studies have demonstrated that inter‐anesthesiologist variability can be a driver of outcomes for high‐risk patients. We hypothesized that anesthesiologist experience, defined as the number of previous liver transplants performed at our institution, the Icahn School of Medicine at Mount Sinai, would be independently associated with outcomes for liver transplant patients.

Subscribe to