Guang Y. Li, Yun Zhou, Ruo S. Ying, Lei Shi, Yong Q. Cheng, Jun P. Ren, Jeddidiah W.D. Griffin, Zhan S. Jia, Chuan F. Li, Jonathan P. Moorman, Zhi Q. Yao – 5 December 2014 – T cells play a crucial role in viral clearance or persistence; however, the precise mechanisms that control their responses during viral infection remain incompletely understood. MicroRNA (miR) has been implicated as a key regulator controlling diverse biological processes through posttranscriptional repression.

M. Bishr Omary, Michael B. Wallace, Emad M. El‐Omar, Rajiv Jalan, Michael H. Nathanson – 5 December 2014

Matthias Hardtke‐Wolenski, Richard Taubert, Fatih Noyan, Maren Sievers, Janine Dywicki, Jerome Schlue, Christine S. Falk, Brita Ardesjö Lundgren, Hamish S. Scott, Andreas Pich, Mark S. Anderson, Michael P. Manns, Elmar Jaeckel – 5 December 2014 – Autoimmune polyendocrine syndrome type 1 (APS‐1) is caused by mutations of the autoimmune regulator (AIRE) gene. Mouse studies have shown that this results in defective negative selection of T cells and defective early seeding of peripheral organs with regulatory T cells (Tregs).

Krasimira Aleksandrova, Tobias Pischon – 5 December 2014

Chahrazade Kantari‐Mimoun, Magali Castells, Ralph Klose, Anna‐Katharina Meinecke, Ursula J. Lemberger, Pierre‐Emmanuel Rautou, Hélène Pinot‐Roussel, Cécile Badoual, Katrin Schrödter, Christoph H. Österreicher, Joachim Fandrey, Christian Stockmann – 5 December 2014 – Angiogenesis is a key feature of liver fibrosis. Although sinusoidal remodeling is believed to contribute to fibrogenesis, the impact of sinusoidal angiogenesis on the resolution of liver fibrosis remains undefined.

Chun‐Ju Chiang, Ya‐Wen Yang, Jin‐De Chen, San‐Lin You, Hwai‐I Yang, Mei‐Hsuan Lee, Mei‐Shu Lai, Chien‐Jen Chen – 5 December 2014 – A national viral hepatitis therapy program was launched in Taiwan in October 2003. This study aimed to assess the impact of the program on reduction of end‐stage liver disease (ESLD) burden. Profiles of national registries of households, cancers, and death certificates were used to derive incidence and mortality of ESLDs from 2000 to 2011.

Igor Maricic, Huiming Sheng, Idania Marrero, Ekihiro Seki, Tatiana Kisseleva, Som Chaturvedi, Natasha Molle, Stephanie A. Mathews, Bin Gao, Vipin Kumar – 5 December 2014 – Innate immune mechanisms leading to liver injury subsequent to chronic alcohol ingestion are poorly understood. Natural killer T (NKT) cells, enriched in the liver and comprised of at least two distinct subsets, type I and II, recognize different lipid antigens presented by CD1d molecules.

Xiang‐Yong Li, Min‐Jun Bai, Lin‐Jun Chen, Jian‐Liang Xu, Zhi‐Huan Lin, Xing Li, Yan‐Fang Xing – 5 December 2014

Xingshun Qi, Xiaozhong Guo, Daiming Fan – 5 December 2014

Jaswinder Singh Maras, Rakhi Maiwall, H.C. Harsha, Sukanta Das, Md.Shabir Hussain, Chandan Kumar, Chhagan Bihari, Archana Rastogi, Manoj Kumar, Nirupama Trehanpati, Shvetank Sharma, Akhilesh Pandey, Shiv Kumar Sarin – 5 December 2014 – Acute‐on‐chronic liver failure (ACLF) is an ailment with high incidence of multiorgan failure (MOF) and consequent mortality. Dysregulated iron homeostasis and macrophage dysfunction are linked to increased incidence of MOF.