Cynthia Tsien, Gangarao Davuluri, Dharmvir Singh, Allawy Allawy, Gabriella A.M. Ten Have, Samjhana Thapaliya, John M. Schulze, David Barnes, Arthur J. McCullough, Marielle P.K.J. Engelen, Nicolaas E.P. Deutz, Srinivasan Dasarathy – 22 January 2015 – Skeletal muscle loss (sarcopenia) is a major clinical complication in alcoholic cirrhosis with no effective therapy. Skeletal muscle autophagic proteolysis and myostatin expression (inhibitor of protein synthesis) are increased in cirrhosis and believed to contribute to anabolic resistance.

Michael L. Volk – 20 January 2015 – Watch a video presentation of this article

Jennifer C. Price, Norah A. Terrault – 20 January 2015 – Although chronic infection with hepatitis C virus (HCV) is the leading indication for liver transplantation in the United States, graft and patient survival rates are reduced because of HCV recurrence after transplant. Interferon‐based antiviral treatment administered either before or after transplant to prevent or treat HCV recurrence, respectively, is limited because of poor tolerability and low efficacy.

20 January 2015

Jean‐François Dufour – 20 January 2015

Raoul Poupon – 20 January 2015 – Several lines of evidence show that serum alkaline phosphatase (AP) is not only a signpost of cholestasis but also a surrogate marker of the severity of primary biliary cirrhosis and primary sclerosing cholangitis. In the present opinion article, we review and discuss the putative role of liver AP in health and in cholestatic diseases.

Fasiha Kanwal – 20 January 2015 – Watch a video presentation of this article

Jayant A. Talwalkar – 20 January 2015 – Watch a video presentation of this article

Peter Bannas, Diego Hernando, Utaroh Motosugi, Alejandro Roldan, Scott Brian Reeder – 20 January 2015 – Watch a video presentation of this article

Peter Bannas, Diego Hernando, Utaroh Motosugi, Alejandro Roldan, Scott Brian Reeder – 20 January 2015 – Watch a video presentation of this article