CD44 and CXCL9 serum protein levels predict the risk of clinically significant allograft rejection after liver transplantation

Nathanael Raschzok, Anja Reutzel‐Selke, Rosa Bianca Schmuck, Mehmet Haluk Morgul, Ulrich Gauger, Kukuh Aji Prabowo, Laura‐Marie Tannus, Annekatrin Leder, Benjamin Struecker, Sabine Boas‐Knoop, Michael Bartels, Sven Jonas, Christian Lojewski, Gero Puhl, Daniel Seehofer, Marcus Bahra, Andreas Pascher, Johann Pratschke, Igor Maximilian Sauer – 6 May 2015 – The diagnosis of acute cellular rejection (ACR) after liver transplantation is based on histological analysis of biopsies because noninvasive biomarkers for allograft rejection are not yet established for clinical routines.

The etiology of cirrhosis is a strong determinant of brain reserve: A multimodal magnetic resonance imaging study

Vishwadeep Ahluwalia, James B. Wade, F. Gerard Moeller, Melanie B. White, Ariel B. Unser, Edith A. Gavis, Richard K. Sterling, R. Todd Stravitz, Arun J. Sanyal, Mohammad S. Siddiqui, Puneet Puri, Velimir Luketic, Douglas M. Heuman, Michael Fuchs, Scott Matherly, Jasmohan S. Bajaj – 4 May 2015 – Poor brain reserve in alcoholic cirrhosis could worsen insight regarding disease severity and increase the patients' vulnerability toward further deterioration.

Declining liver graft quality threatens the future of liver transplantation in the United States

Eric S. Orman, Maria E. Mayorga, Stephanie B. Wheeler, Rachel M. Townsley, Hector H. Toro‐Diaz, Paul H. Hayashi, A. Sidney Barritt – 4 May 2015 – National liver transplantation (LT) volume has declined since 2006, in part because of worsening donor organ quality. Trends that degrade organ quality are expected to continue over the next 2 decades. We used the United Network for Organ Sharing (UNOS) database to inform a 20‐year discrete event simulation estimating LT volume from 2010 to 2030. Data to inform the model were obtained from deceased organ donors between 2000 and 2009.

Intracardiac thrombosis during liver transplant: A 17‐year single‐institution study

Prith Peiris, Sher‐Lu Pai, Stephen Aniskevich, Claudia C. Crawford, Klaus D. Torp, Beth L. Ladlie, Timothy S. Shine, C. Burcin Taner, Justin H. Nguyen – 4 May 2015 – Intracardiac thrombosis (ICT) during orthotopic liver transplantation (OLT) is an uncommon event. However, it is a devastating complication with high mortality when it occurs. This study aimed to identify possible predisposing factors for ICT during OLT. We retrospectively identified the cases of all patients with ICT during OLT at our institution from 1998 to 2014. Of 2750 OLTs performed, 10 patients had ICT intraoperatively.

The protective function of galectin‐9 in liver ischemia and reperfusion injury in mice

Hirofumi Hirao, Yoichiro Uchida, Kentaro Kadono, Hirokazu Tanaka, Toshiro Niki, Akira Yamauchi, Koichiro Hata, Takeshi Watanabe, Hiroaki Terajima, Shinji Uemoto – 30 April 2015 – Galectin‐9 (Gal‐9) has gained attention as a multifaceted player in adaptive and innate immunity. To elucidate the role of Gal‐9, we used a mouse model of partial liver ischemia/reperfusion injury (IRI) with wild type (WT) and Gal‐9 knockout (KO) mice as well as a recombinant galectin‐9 (reGal‐9) protein.

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