This workshop addresses how AI is revolutionizing the life sciences in hepatology and increasingly permeating the world of basic science. AI tools can be used for experimental design and modeling. AlphaFold, a landmark AI tool developed to predict protein conformation, is informing the development of small molecule inhibitors for different conditions. Other AI applications in basic research include sequencing, imaging, and structural biology. AI is being used to integrate clinical and high-throughput omics data for personalized diagnostic predictions and promises to inform individualized therapeutic approaches.