Prakash Ramachandran, MBChB MRCP(UK) BSc(Hons) PhD

Biography

I am an Academic Hepatologist and Professor of Experimental Hepatology at the University of Edinburgh in the UK. My research over the past 15 years has focussed on the role of the immune system in regulating tissue fibrosis. Having initially studied macrophage heterogeneity in murine models of fibrosis during my PhD (2008-2011), over the past 10 years I have employed single-cell and spatial technologies to study inflammatory and fibrogenic mechanisms in human liver fibrosis. I have extensive experience and expertise in single cell/single nuclear RNA sequencing (sc/snRNA-seq) and spatial transcriptomics to study the liver and other tissues. The importance of this work has been recognized by prizes from national and international societies (e.g. 2020 European Association for the Study of the Liver (EASL) Emerging Leader award and 2020 United European Gastroenterology (UEG) Rising Star Award). I have subsequently been awarded an MRC Senior Clinical Fellowship, where we are employing single-cell and spatial transcriptomics on human liver biopsy tissue at early-stage disease to identify novel therapeutic targets for liver fibrosis.