Cell-Molecule Circuitry of Hepatobiliary Repair 

Description

In this session, panel members discuss recent advances in understanding the cellular and molecular basis of hepatobiliary repair. The concepts covered by thought leaders and content experts include the roles of various metabolic zones in the liver lobule in maintaining hepatic homeostasis as well as in regeneration following injury or resection; and the balance of metabolic/synthetic function and proliferation during liver repair and what controls such balance. Presenters also address the concepts of hepatocyte to cholangiocyte reprogramming and vice versa (ie, transdifferentiation) during specific chronic pathologies affecting cholangiocytes and hepatocytes, respectively. Finally, panelists review synthetic biology approaches including the use of personalized hepatic organoids and gene editing for understanding rare and orphan liver diseases.