Cholestatic Liver Disease

Primary biliary cholangitis (PBC) is a chronic liver disorder caused by progressive bile duct destruction. In this post, we will present the characteristic histologic findings of PBC, as well as the...

Is obeticholic acid effective in the treatment of patients with PBC?

Learn about the diagnostic approach to cholestasis in pediatrics, focused on a case of a 5-day-old baby with persistence jaundice and hyperbilirubinemia.

25-year-old female with hyperthyroidism who is 30 weeks pregnant initially presented with costovertebral tenderness, pelvic pain and nausea. Pain resolved after passing a kidney stone, but  initial...

Ursodeoxycholic acid (or UDCA, Ursodiol) is a very commonly-used medication in the hepatologist’s arsenal. But have you ever wondered what it is? Why does it work? I know I have. Let’s try and answer...

Why, after an episode of prolonged biliary obstruction, or after severe forms of acute liver injury, does the alkaline phosphatase (ALP) rise in a delayed fashion? And why do the ALP and total...