With advances in surgical techniques, multidisciplinary care, and immunosuppression, patient and graft survival continue to improve in liver transplantation. Excellent patient and graft survival have translated into an aging liver transplant recipient cohort that resembles a general chronic disease population. This session addresses the complexity of long-term care of liver transplant survivors, strategies to mitigate morbidity, and approaches to promote the long-term health and well-being of liver transplant recipients.