Associate editors from the journal Hepatology—Drs Kari Nejak-Bowen, Natalie Torok, and Samar Ibrahim—critically discuss the most noteable, influential, cutting-edge, game-changing basic and translational research papers published in Hepatology and elsewhere during the past year. A panel discussion with the speakers, Hepatology Editor-in-Chief Dr Gregory Gores, and Hepatology Deputy Editor Dr Harmeet Malhi focuses on the impact of selected papers on basic and translational advances in the field.