The Crosstalk of Immune Cells and Portal Fibroblasts in Liver Fibrogenesis

Nov 18 2024
Convention Center: Room 25 C
12:45 PM - 1:30 PM
Ticketed Event

World Class Speakers

Tatiana Kisseleva, MD, PhD
Discussion Leader

Tatiana Kisseleva, MD, PhD

University of California, San Diego

Description

Portal fibroblasts (PFs) are implicated in the pathogenesis of cholestatic fibrosis. Proliferation and activation of PFs is mediated by the crosstalk between immune cells and cholangiocytes. Experts discuss pathways of PF activation; composition and heterogeneity of PFs; functional roles of PFs and hepatic stellate cells; and potential strategies for the development of novel antifibrotic therapies for the treatment of cholestatic fibrosis.

 

Journey Maps

Objectives

  • Describe the pathways of portal fibroblast (PF) activation.
  • Review the composition and heterogeneity of PFs.
  • Compare the functional roles of PFs and hepatic stellate cells.
  • Discuss potential therapeutic strategies for treatment of cholestatic fibrosis.