Tatiana Kisseleva, MD, PhD

Biography

I received my MD at Russian University of Friendship, Moscow. I then studied biochemistry and immunology during my graduate studies at Christian-Albrecht University, Germany. As a postdoctoral fellow at Columbia University (USA), I studied signal transduction, and expanded my skills in transgenic mouse technologies. I joined UCSD as a principal investigator. The major interest of my research is the identification of new targets for the therapy of MASH and MetALD-associated liver fibrosis and cholestatic fibrosis. Specifically, we focus our research on profiling the gene expression profiles and epigenetic landscapes of mouse and human hepatic myofibroblasts to understand the mechanism of the development and regression of liver fibrosis. To translate our findings into patients, our laboratory has obtained extensive experience with isolation and cryopreservation of human hepatocytes, Kupffer cells, and Endothelial Cells from livers declined for transplantation, and generation of xenograft models of liver fibrosis in mice.