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Mitochondrial Dysfunction in Metabolic Dysfunction-Associated Steatotic Liver Disease and Metabolic Dysfunction-Associated Steatohepatitis: Targeting Fibrosis and Hepatic Damage

Description

Speakers discuss the role of intracellular intricacies, including mitochondrial proteins, and their role in fatty liver disease as it relates to hepatic fibrosis. Presenters also describe human disease progression in obese and lean patient disease phenotypes along with animal models recapitulating metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH). 

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Objectives

  • Describe mitochondrial biogenesis, autophagy, mitophagy, fission, and fusion within the context of fibrosis-driven MASLD/MASH disease.
  • Explain the role of megamitochondria and mitochondrial maladaptation in fatty liver fibrosis.