This basic science symposium delves into the intricate interplay between metabolism and liver cancer. The program brings together leading experts, researchers, and scientists from various fields to explore cutting-edge developments in the understanding of how metabolic processes impact the development and progression of liver malignancies. The session includes presentations on metabolic reprogramming; metabolic competition between cancer cells and cells of the tumor microenvironment; immunometabolism; metabolic plasticity; and therapeutic opportunities targeting liver cancer metabolism. Growing awareness of the significance and prevalence of these mechanisms is leading to a deeper understanding of their involvement in tumor initiation and advancement. This understanding, in turn, is guiding basic and translational liver cancer research to identify metabolic vulnerabilities of liver cancers that might be exploited as therapeutic strategies.