Thomas Marjot, MRCP DPhil

Biography

I am a Gastroenterology and Hepatology Specialist Registrar at Oxford University Hospitals and an NIHR Academic Clinical Lecturer at the University of Oxford. After graduating from Imperial College London (2012), I have since moved through the integrated academic training pathway as an Academic Clinical Fellow and now Lecturer in Oxford. Over the last 10 years I have developed and applied a range of experimental medicine techniques to decipher the metabolic pathways leading to metabolic dysfunction-associated steatotic liver disease (MASLD). This has included the use of insulin infusion studies, stable isotope assessments of glucose and lipid handling, and analysis of tissue biopsies using multi-omics platforms. More recently, I have developed an interest in circadian regulation of metabolism and during a Wellcome Trust Clinical Research Training Fellowship I completed a DPhil in 2023 which investigated the role of circadian rhythms in the pathogenesis of MASLD. I am currently working on translational human projects relating to diurnal patterns of metabolism, shift-worker health, sleep and glucose control, chronopharmacology, and the assessment of behavioural rhythms using wearable technology. I also have a specialist interest in sleep-wake disturbance in patients with cirrhosis and hepatic encephalopathy