Hayato Nakagawa, MD, PhD

Biography

Current and Past Positions
04/2000 Resident, Mitsui Memorial Hospital
06/2005 Medical Doctor, Department of Gastroenterology, The University of Tokyo Hospital
06/2011 Postdoctoral fellow, University of California, San Diego
04/2013 Assistant Professor, Department of Gastroenterology, The University of Tokyo Hospital
04/2019 Specially Appointed Lecturer, Department of Gastroenterology, The University of Tokyo Hospital
08/2021- Professor and Chairman, Department of Gastroenterology and Hepatology, Mie University

Education
2000 M.D. Mie University, School of Medicine
2009 Ph.D. The University of Tokyo, Graduate School of Medicine

Special field of research
Molecular mechanisms of hepatobiliary injury and carcinogenesis

International Awards
2012 AASLD Fellow Research Award
2014 ILCA Junior Investigator Award
2016 APASL Presidential Award
2017 JDDW Rising Star Award

Editorial Board Membership
Hepatology, Editorial Board Member
Journal of Hepatology, Editorial Board Member
Journal of Gastroenterology, Associate Editor
Hepatology Research, Associate Editor

Selected Publications
1. Kawamura S, Nakagawa H (Corresponding author), et al. Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatoheopatitis. J Clin Invest. 2022.
2. Hayata Y, Nakagawa H (Corresponding author), et al. Axin2+ peribiliary glands in the periampullary region generate biliary epithelial stem cells that give rise to ampullary carcinoma. Gastroenterology. 2021.
3. Fujiwara N, Nakagawa H (Corresponding author), et al. CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity. Gut. 2018.
4. Nakagawa H, et al. Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands. Proc Natl Acad Sci U S A. 2017.
5. Nakagawa H, et al. ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. Cancer Cell. 2014.
6. Nakagawa H, et al. Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis. Proc Natl Acad Sci U S A. 2014.
7. He G*, Dhar D*, Nakagawa H* (Co-first author), et al. Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling. Cell. 2013.