Associate editors from the journal Hepatology—Drs Juan Abraldes, Jacqueline O'Leary, and Alina Allen—critically discuss the most notable, influential, cutting edge, game changing clinical research papers published in Hepatology and elsewhere during the past year. A panel discussion with the speakers, Hepatology Editor-in-Chief Dr Gregory Gores, and Hepatology Deputy Editor Dr Harmeet Malhi focuses on the clinical impact of selected papers, and key challenges and opportunities in the field.