Presenters in this 2-part session dissect the intricate relationship between metabolic dysfunction-associated steatotic liver disease (MASLD), alcohol-associated liver disease (ALD), and the overlapping entity MetALD. Renowned experts explore these entities in terms of epidemiology, etiology, clinical diagnostics, and therapeutic approaches. Presenters delve into whether these conditions are distinct, overlapping, or part of a disease continuum by scrutinizing molecular, histologic, and epidemiologic evidence, and discuss future directions in screening, stratification, and drug development. Join this session to: (1) gain insights into the nuances that differentiate MASLD, ALD, and MetALD and the evidence supporting a spectrum or continuum of disease; (2) expand knowledge to apply advanced diagnostic tools effectively in clinical practice; (3) hone diagnostic and therapeutic strategies; and (4) develop a deeper understanding of the treatment landscape, unmet needs, and future directions in therapy and research for these liver diseases.
Metabolic Dysfunction-Associated Steatotic Liver Disease, Alcohol-Associated Liver Disease, and MetALD: Three Different Entities or Overlap and Continuation?
Norah Terrault, MD, MPH, FAASLD, Presenter
ALD
MASLD
8:15 AM - 8:30 AM
Nov
16
2024
San Diego, CA
Molecular Evidence for the Three Entities
Anna Mae Diehl, MD, FAASLD, Presenter
ALD
MASLD
8:30 AM - 8:45 AM
Nov
16
2024
San Diego, CA
Histologic Evidence for Metabolic Dysfunction-Associated Steatotic Liver Disease, Alcohol-Associated Liver Disease, and MetALD
Cindy A Behling, MD, Ph.D, Presenter
ALD
MASLD
8:45 AM - 9:00 AM
Nov
16
2024
San Diego, CA
Screening and Stratifying in Metabolic Dysfunction-Associated Steatotic Liver Disease Versus Alcohol-Associated Liver Disease Versus MetALD
Luis Antonio Diaz, MD, Presenter
ALD
MASLD
9:00 AM - 9:30 AM
Nov
16
2024
San Diego, CA
Panel Discussion
Alina M. Allen, MD, Moderator
ALD
MASLD
Objectives
Describe the distinctions and potential overlaps in the prevalence, progression, and outcomes of MASLD, ALD, and MetALD.
Discuss the current and emerging diagnostic modalities used to distinguish between MASLD, ALD, and MetALD, particularly in the context of use of AI to enhance histologic interpretation.
Review the impact of therapeutic interventionsspecifically those targeting the gut-liver axis and metabolic pathways in MASLD and MetALDand the design and outcomes of clinical trials in this domain.