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Basic Science Symposium: Metabolic Landscape and Networks in Hepatobiliary Malignancies, Part 2

Description

This basic science symposium delves into the intricate interplay between metabolism and liver cancer. The program brings together leading experts, researchers, and scientists from various fields to explore cutting-edge developments in the understanding of how metabolic processes impact the development and progression of liver malignancies. The session includes presentations on metabolic reprogramming; metabolic competition between cancer cells and cells of the tumor microenvironment; immunometabolism; metabolic plasticity; and therapeutic opportunities targeting liver cancer metabolism. Growing awareness of the significance and prevalence of these mechanisms is leading to a deeper understanding of their involvement in tumor initiation and advancement. This understanding, in turn, is guiding basic and translational liver cancer research to identify metabolic vulnerabilities of liver cancers that might be exploited as therapeutic strategies.

Journey Maps

Presentations

11:00 AM - 11:20 AM
Nov 15 2024
San Diego, CA

Cancer Cell Metabolism: From Epigenetic Modifications to Transcriptional Regulation

Renumathy Dhanasekaran, MD, PhD, Presenter
Basic Science
11:20 AM - 11:40 AM
Nov 15 2024
San Diego, CA

Metabolic Susceptibility to Cell Death

Lichun Ma, PhD, Presenter
Basic Science
11:40 AM - 12:00 PM
Nov 15 2024
San Diego, CA

Genetic Alterations as Mechanisms Underlying Cancer Cell Metabolic Alterations

Kaisa Hanley, PhD, Presenter
Basic Science
12:15 PM - 12:30 PM
Nov 15 2024
San Diego, CA

Panel Discussion

Nicole E Rich, MD, MSCS, Moderator
Basic Science
12:07 PM - 12:07 PM
Nov 15 2024
San Diego, CA

Q&A (After each Presentation)

Davide Povero, PhD, MBA, Moderator
Basic Science

Objectives

  • Identify mechanisms of metabolic rewiring promoting liver cancer development and progression.
  • Describe metabolic competition between tumor cells and metabolic reprogramming of immune cells (immunometabolism).
  • Define the relationship between cancer mutations, metabolic plasticity, and vulnerabilities.
Chair

Daniela Sia, PhD

Icahn School of Medicine at Mount Sinai