Pediatric Hepatology - Basic Science
Nov
13
2023
Room 312
-
Hynes Convention Center
2:00
- 3:30 PM EST
Speakers
Description
Novel basic science advances have transformed the understanding of etiopathogenesis and diagnosis of many childhood liver disorders. This session highlights the application of novel scientific approaches to cholestatic liver disease and liver failure.
Abstracts
- SPATIALLY RESOLVED EXPANSION OF REGULATORY IMMUNE CELLS MAY PREDICT CLINICAL OUTCOMES IN PEDIATRIC ACUTE LIVER FAILURE
- CILIARY AND CELL STRUCTURE GENE VARIANTS CONTRIBUTE TO THE ETIOPATHOGENESIS OF BILIARY ATRESIA (BA): EXOME AND SNP ARRAY ANALYSIS OF >1700 NORTH AMERICAN CHILDREN WITH BA
- BILIARY ATRESIA CANDIDATE GENE Pkd1l1 IS ESSENTIAL FOR MAINTENANCE OF BILIARY EPITHELIAL CELL INTERACTION AND INFLAMMATORY RESPONSE
- DEVELOPING A THERAPEUTIC MODEL FOR INTRAHEPATIC CHOLESTASIS BY MODULATING THE INTESTINAL MICROBIOME
- STAT3 SIGNALING MEDIATES FXR AGONIST PROTECTION IN ACUTE CHOLANGIOPATHY MOUSE MODEL
- SPATIAL TRANSCRIPTOMICS IDENTIFIES IMMUNE EXPANSION OF SCAR REGIONS AND REDUCED HEPATOCYTE ZONATION IN LIVERS FROM PATIENTS WITH BILIARY ATRESIA
Objectives
- Attendees will evaluate the application of novel basic science techniques in childhood liver disease.
- Learn about novel developments in the understanding of the etiopathogenesis of cholestatic liver disease.
- Identify the role of molecular genetics and cell signaling on the development childhood liver disease.